Treg Cells and Epigenetic Regulation
Treg Cells and Epigenetic Regulation
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DOI：
10.1007/978-981-15-6407-9_6
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发表时间：
2021-01-01
期刊：
影响因子：
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通讯作者：
Li, Dongmei
中科院分区：
文献类型：
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作者：
Bellanti, Joseph A.;Li, Dongmei
Treg细胞是一种具有基本免疫调节特性的细胞群体，其表观遗传调控的发现为理解这些细胞在健康和疾病中的作用提供了相当多的见解。过去几年的研究表明，Treg细胞与肠道微生物群的相互作用不仅对于健康中Treg功能的发展至关重要，而且对于在人类疾病如过敏性疾病、自身免疫性疾病和癌症的发病机制中起关键作用的Treg功能异常也至关重要。Treg细胞的表型可塑性和稳定性之间的平衡由确保Foxp3在Treg细胞中稳定表达所需的微调转录和表观遗传事件定义。在本章中，我们讨论了控制Foxp 3基因表达的分子事件，并讨论了DNA甲基化作为调节Treg诱导基因表达的重要分子开关的重要性，以及这些发现对治疗以Treg细胞功能异常为特征的人类疾病的可能影响。
The discovery of the epigenetic regulation of Treg cells, a cell population with fundamental immunoregulatory properties, has shed considerable insights into an understanding of the role of these cells in health and disease. Research over the past several years has shown that the interaction of Treg cells with the gut microbiota are critical not only for the development of Treg function in health but also for abnormalities of Treg function that play a critical role in the pathogenesis of human diseases such as the allergic diseases, the autoimmune disorders, and cancer. The equilibrium between phenotypic plasticity and stability of Treg cells is defined by the fine-tuned transcriptional and epigenetic events required to ensure stable expression of Foxp3 in Treg cells. In this chapter, we discuss the molecular events that control Foxp3 gene expression and address the importance of DNA methylation as an important molecular switch that regulates the genetic expression of Treg induction and the possible implications of these findings for the treatment of human diseases characterized by abnormalities of Treg cell function.