Apolipoproteins AI, AII, and CI stimulate placental lactogen release from human placental tissue. A novel action of high density lipoprotein apolipoproteins.
Apolipoproteins AI, AII, and CI stimulate placental lactogen release from human placental tissue. A novel action of high density lipoprotein apolipoproteins.
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载脂蛋白 AI、AII 和 CI 刺激人胎盘组织释放胎盘催乳素。
DOI：
10.1172/jci112857
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Harman,I
中科院分区：
文献类型：
--
作者：
Handwerger,S;Quarfordt,S;Barrett,J;Harman,I
高密度脂蛋白(HDL)刺激人胎盘外植体释放胎盘催乳素(HPL)呈剂量依赖性增加。这种刺激不能被高密度脂蛋白的脱脂所阻止，但可以被胰酶消化完全阻断。去脂载脂蛋白AI、AII和CI也能刺激HPL的释放，而其他载脂蛋白则无此作用。高密度脂蛋白和载脂蛋白CI对大鼠垂体细胞黄体生成素和卵泡刺激素的释放以及人蜕膜细胞催乳素的释放均无影响。由于胎盘细胞具有特定的高密度脂蛋白受体，血浆高密度脂蛋白浓度在妊娠期间升高，这些结果强烈地表明高密度脂蛋白在妊娠期间调节HPL的释放可能独立于它们在血浆脂质运输中的通常作用。
High density lipoproteins (HDL) stimulated a dose-dependent increase in the release of placental lactogen (hPL) from human placental explants. The stimulation was not prevented by delipidation of HDL but was completely blocked by tryptic digestion. Delipidated apolipoproteins (Apo) AI, AII, and CI also stimulated hPL release but other apolipoproteins were without effect. HDL and Apo CI had no effects on the release of luteinizing hormone and follicle-stimulating hormone from rat pituitary cells or the release of prolactin from human decidual cells. Because placental cells have specific HDL receptors and plasma HDL concentrations increase during pregnancy, these results strongly suggest a role for HDL in the regulation of hPL release during pregnancy possibly independent of their usual role in plasma lipid transport.