Reactivity of isolated human cerebral arteries to biogenic amines.
Reactivity of isolated human cerebral arteries to biogenic amines.
复制标题
离体人脑动脉对生物胺的反应性。
DOI：
10.1159/000158143
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
W. Murakami
中科院分区：
文献类型：
--
作者：
S. Shibata;J. Cheng;W. Murakami
血清素（5-HT）、组胺、去甲肾上腺素、甲氧胺和异丙肾上腺素引起人脑动脉的剂量依赖性收缩。5-HT的效价在基底动脉中较高，与去甲肾上腺素在人大脑前、中、后动脉中的效价相当。乙酰胆碱和甲胆碱(10（-9)-10(-5)M）在人脑动脉中引起的反应可以忽略不计。对5-HT的收缩反应在人基底动脉的远端比中间部分更大，而对去甲肾上腺素的反应则相反。乳胺（10(-4)M）引起强直性收缩，尼古丁（10(-4)M）和电跨壁刺激引起动脉的相性收缩，并被肾上腺素能阻滞剂拮抗。腺嘌呤核苷酸不能引起松弛，只有高浓度的腺苷能引起一分钟的松弛。然而，罂粟碱和硝化甘油引起明显的松弛。提示肾上腺素能机制可能参与了人脑动脉血管张力的调节。
Serotonin (5-HT), histamine, norepinephrine, methoxamine and isoproterenol caused dose-dependent contraction of human cerebral arteries. The potency of 5-HT was greater among test agents in the basilar arteries, whereas it was equivalent to that of norepinephrine in human anterior, middle and posterior cerebral arteries. Acetylcholine and carbachol (10(-9)-10(-5) M) caused a negligible response in human cerebral arteries. Contractile response to 5-HT was greater in the distal rather than middle portion of the human basilar arteries while this order was reversed in the response to norepinephrine. Tyramine (10(-4) M) caused tonic contraction and nicotine (10(-4) M) and electrical transmural stimulation produced phasic contraction of arteries which were antagonized by adrenergic blocking agents. Adenine nucleotides failed to cause relaxation and only high concentration of adenosine caused a minute relaxation. However, papaverine and nitroglycerin caused marked relaxation. These results suggest that adrenergic mechanism may play a role in the regulation of vascular tone in human cerebral arteries.