Mitotic entry - A matter of oscillating destruction
Mitotic entry - A matter of oscillating destruction
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DOI：
10.4161/cc.4.11.2192
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发表时间：
2005-11-01
期刊：
影响因子：
4.3
通讯作者：
Duyster, J
中科院分区：
文献类型：
--
作者：
Bassermann, F;Peschel, C;Duyster, J
进入有丝分裂基本上是由细胞周期蛋白B1及其相关的催化活性伴侣Cdk 1驱动的。虽然细胞周期蛋白B1保持在整个间期细胞质中，但在有丝分裂之前发生核积累。这种限制被认为是一个振荡机制的一部分，以正确的时间有丝分裂进入。一种新的核SCF型哺乳动物E3连接酶，由含F-box的蛋白NIPA（ALK的核相互作用伴侣）定义，SCFNIPA，在间期靶向核细胞周期蛋白B1，同时允许在G（2）/M处积累。因此，由SCFNIPA复合物驱动的核细胞周期蛋白B1的振荡泛素化有助于哺乳动物细胞周期中有丝分裂进入的时机。
Entry into mitosis is essentially driven by cyclin B1 and its associated catalytically active partner Cdk1. While cyclin B1 is kept cytoplasmic throughout interphase, nuclear accumulation occurs just prior to mitosis. This restriction is thought to be part of an oscillating mechanism to properly time mitotic entry. A novel nuclear SCF-type mammalian E3 ligase defined by the F-box containing protein NIPA ( nuclear interaction partner of ALK), SCFNIPA, targets nuclear cyclin B1 in interphase while it allows for accumulation at G(2)/M. Thus, oscillating ubiquitination of nuclear cyclin B1 driven by the SCFNIPA complex contributes to the timing of mitotic entry in the mammalian cell cycle.