Patterned cell and matrix dynamics in branching morphogenesis.
Patterned cell and matrix dynamics in branching morphogenesis.
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DOI：
10.1083/jcb.201610048
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发表时间：
2017-03-06
期刊：
影响因子：
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通讯作者：
Yamada KM
中科院分区：
文献类型：
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作者：
Wang S;Sekiguchi R;Daley WP;Yamada KM
Wang等人讨论了胚胎发生过程中形成肺、肾和血管等器官分支结构所需的复杂过程。许多胚胎器官经历分支形态发生以最大化其功能性上皮表面积。分支形态发生需要多种类型的细胞与细胞外基质（ECM）的协调相互作用。在分枝形态发生过程中，新的分枝通过“出芽”或“劈裂”形成。细胞迁移、增殖、重排、变形和ECM动力学在驱动不同器官中的出芽与分裂中具有不同的作用。新形成的分支的伸长和尖端的最终成熟涉及细胞机制，包括细胞伸长、插入、会聚延伸、增殖和分化。高分辨率实时成像、张力传感器和力映射技术等新方法为未来分支形态发生的研究提供了令人兴奋的新机会。
Wang et al. discuss the intricate processes required during embryogenesis for the formation of the branched architecture of organs such as the lung, kidney, and blood vessels. Many embryonic organs undergo branching morphogenesis to maximize their functional epithelial surface area. Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM). During branching morphogenesis, new branches form by “budding” or “clefting.” Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs. Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation. New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.