Contribution to the kinetics and amplitude of the electroretinogram b-wave by third-order retinal neurons in the rabbit retina
Contribution to the kinetics and amplitude of the electroretinogram b-wave by third-order retinal neurons in the rabbit retina
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DOI：
10.1016/s0042-6989(99)00203-5
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发表时间：
2000-01-01
期刊：
影响因子：
1.8
通讯作者：
Hare, WA
中科院分区：
文献类型：
--
作者：
Dong, CJ;Hare, WA
ERG b波被广泛认为主要反映中心双极细胞和米勒细胞的光诱导活动。三级视网膜神经元被认为对b波的产生贡献微不足道。在这里，我们表明，主要影响三级神经元的药物显著改变了b波的动力学和幅度。我们的结果支持这一观点，即三级神经元右诱发的膜去极化的幅度和动力学的变化与b波的幅度和动力学的变化类似。我们得出结论，三阶神经元的活动对b波的产生有重要贡献。我们的结果还提供了证据，证明三阶神经元的放电活动通过加速b波的开始而截断a波。(C)2000爱思唯尔科学有限公司。保留所有权利。
The ERG b-wave is widely believed to reflect mainly light-induced activity of on-center bipolar cells and Muller cells. Third-order retinal neurons are thought to contribute negligibly to generation of the b-wave. Here we show that pharmacological agents which affect predominantly third-order neurons alter significantly both the kinetics and amplitude of the b-wave. Our results support the notion that changes in the amplitude and kinetics of right-induced membrane depolarization in third-order neurons produce similar changes in the amplitude and kinetics of the b-wave. We conclude that activity in third-order neurons makes a significant contribution to b-wave generation. Our results also provide evidence that spiking activity of third-order neurons truncates the a-wave by accelerating the onset of the b-wave. (C) 2000 Elsevier Science Ltd. All rights reserved.