A REVERSIBLE PROTECTING GROUP FOR THE AMIDE BOND IN PEPTIDES - USE IN THE SYNTHESIS OF DIFFICULT SEQUENCES
A REVERSIBLE PROTECTING GROUP FOR THE AMIDE BOND IN PEPTIDES - USE IN THE SYNTHESIS OF DIFFICULT SEQUENCES
复制标题
DOI：
10.1039/c39930000369
复制
发表时间：
1993-02-21
影响因子：
--
通讯作者：
SHEPPARD, RC
中科院分区：
文献类型：
--
作者：
JOHNSON, T;QUIBELL, M;SHEPPARD, RC
N（α）-（2-羟基-4-甲氧基苄基）氨基酸5的N，O-Bis-Fmoc（芴-9-基甲氧羰基）衍生物是制备具有可逆保护的（叔）肽键的肽的有用中间体;它们在固相肽合成期间抑制链间缔合的价值已得到证实。
N,O-Bis-Fmoc (fluoren-9-ylmethoxycarbonyl) derivatives of N(alpha)-(2-hydroxy-4-methoxybenzyl)amino acids 5 are useful intermediates for the preparation of peptides with reversibly protected (tertiary) peptide bonds; their value in inhibiting interchain association during solid phase peptide synthesis is demonstrated.