VEGF and podocytes in diabetic nephropathy.
VEGF and podocytes in diabetic nephropathy.
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DOI：
10.1016/j.semnephrol.2012.06.010
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发表时间：
2012-07
影响因子：
3.3
通讯作者：
Veron, Delma
中科院分区：
文献类型：
--
作者：
Tufro, Alda;Veron, Delma
关键词：
Vascular endothelial growth factor-a (VEGF-A) is a protein secreted by podocytes that is necessary for survival of endothelial cells, podocytes and mesangial cells. VEGF-A regulates slit-diaphragm signaling and podocyte shape via VEGFR2-nephrin-nck-actin interactions. Chronic hyperglycemia-induced excess podocyte VEGF-A and low endothelial nitric oxide drive the development and the progression diabetic nephropathy. The abnormal cross talk between VEGF-A and NO pathways is fueled by the diabetic milieu increased oxidative stress. Recent findings on these pathogenic molecular mechanisms provide new potential targets for therapy for diabetic renal disease.
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