Clinical report of three cases of acute radiation sickness from a 60Co radiation accident in Henan province in China
Clinical report of three cases of acute radiation sickness from a 60Co radiation accident in Henan province in China
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DOI：
10.1269/jrr.07071
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发表时间：
2008-01-01
影响因子：
2
通讯作者：
Jiang, Enhai
中科院分区：
文献类型：
--
作者：
Liu, Qiang;Jiang, Bo;Jiang, Enhai
1999年4月26日，三人意外受到高剂量钴-60辐照。他们患有严重（1例）和中度（2例）造血型急性放射病（ARS）。作为综合治疗的一部分，应用严格的反向隔离和粒细胞-巨噬细胞集落刺激因子（GM-CSF）治疗。所有患者经适当治疗83天后均痊愈。早期正确的诊断和有效的治疗，有助于病人脱离急性放射病的危险期。为了避免女性患者在关键期月经，我们用睾酮改变了她的月经周期。我们认为，应尽早给予足够剂量的GM-CSF，以促进早期血液重建。从这些病人的医疗管理中获得的经验是有价值的，在未来的治疗这类病人。
On 26 April 1999, three persons were accidentally exposed by high dose Co-60 irradiation. They suffered from severe (one case) or moderate (two cases) hemopoietic form of acute radiation sickness (ARS). As part of the comprehensive treatment, strict reverse isolation and granulocyte-macrophage colony-stimulating factor (GM-CSF) therapy were applied. All the patients recovered after an appropriate treatment for 83 days. In our experience, the correct diagnosis and effective treatment at an early stage proved to be helpful to the patients in pulling out from the critical stage of acute radiation sickness. To avoid menstruation by the female patient just in the critical stage, we modified her menstruation cycle by testosterone. In our view, GM-CSF should be given as early as possible with enough dosage for promoting early hematological reconstruction. The experience obtained from the medical management of these patients is valuable for the treatment of such patients in the future.