The mouse Rn locus: S allele of the renin regulator gene results from a single structural gene duplication.
The mouse Rn locus: S allele of the renin regulator gene results from a single structural gene duplication.
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小鼠 Rn 位点：肾素调节基因的 S 等位基因由单个结构基因重复产生。
DOI：
10.1002/j.1460-2075.1982.tb01332.x
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
F. Rougeon
中科院分区：
文献类型：
--
作者：
J. Panthier;I. Holm;F. Rougeon
近交系小鼠分为两个不同的表型组，它们在颌下腺（SMG）中具有不同水平的受雄激素调节的肾素活性。携带位于1号染色体上的肾素基因调节子的Rnrs等位基因的菌株具有高水平的肾素活性;携带Rnrb等位基因的菌株具有低水平的肾素活性。SMG的肾素活性水平与肾素mRNA水平相关。我们分析了，Southern印迹杂交，组织中的两个菌株的肾素基因。携带Rnrb等位基因的品系，如BALB/c或C57 B1/6或CH 3小鼠，每个单倍体基因组具有一个肾素结构基因，而那些具有Rnrs等位基因的品系，如AKR或Swiss小鼠，具有两个肾素基因。我们还鉴定了属于不同生化类群的小鼠的肾素基因：小家鼠有一个肾素基因，而M。vrania和M.短吻肌有两个肾素基因。
Inbred strains of mice have been divided into two distinct phenotypic groups having different levels of renin activity regulated by androgen in the submaxillary gland (SMG). Strains carrying the Rnrs allele of the renin gene regulator, located on chromosome 1, have a high level of renin activity; strains carrying the Rnrb allele have a low level of renin activity. The level of SMG renin activity correlates with the level of renin mRNA. We have analyzed, by Southern blot hybridization, the organization of renin genes in both strains. Strains carrying the Rnrb allele, such as BALB/c or C57 Bl/6, or CH3 mice, have one renin structural gene per haploid genome, while those having the Rnrs allele, such as AKR or Swiss mice, have two renin genes. We have also identified renin genes in mice belonging to different biochemical groups: Mus spretus has one renin gene while M. vrania and M. musculus brevirostris have two renin genes.