Ultrasound indentation of bovine knee articular cartilage in situ
Ultrasound indentation of bovine knee articular cartilage in situ
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DOI：
10.1016/s0021-9290(03)00163-5
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发表时间：
2003-09-01
影响因子：
2.4
通讯作者：
Jurvelin, JS
中科院分区：
文献类型：
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作者：
Laasanen, MS;Saarakkala, S;Jurvelin, JS
我们较早时已发展出一种手持式超音波压痕仪器，用于诊断关节软骨退化。在超声压痕中，软骨被超声换能器压缩。根据A模式超声信号计算组织厚度和变形，并使用应变计记录所施加的应力。在这项研究中，超声压痕仪的适用性，以量化牛膝关节软骨的机械声学性能的网站依赖性的变化进行了研究。从股骨内侧髁（FMC）、髌股沟外侧小面（LPG）和内侧胫骨平台（MTP）制备骨软骨块（每个部位n = 6）。使用超声压痕仪原位获得的腕关节刚度（动态模量，E（dyn））与使用体外参考材料测试装置获得的值高度线性相关（r = 0.913，p < 0.01）。超声压痕测量的重现性（标准化变异系数）分别为E（dyn）、关节面超声反射系数（R）和厚度的5.2%、1.7%和3.1%。E（dyn）和R具有部位依赖性（p
We have earlier developed a handheld ultrasound indentation instrument for the diagnosis of articular cartilage degeneration. In ultrasound indentation, cartilage is compressed with the ultrasound transducer. Tissue thickness and deformation are calculated from the A-mode ultrasound signal and the stress applied is registered with the strain gauges. In this study, the applicability of the ultrasound indentation instrument to quantify site-dependent variation in the mechano-acoustic properties of bovine knee cartilage was investigated. Osteochondral blocks (n = 6 per site) were prepared from the femoral medial condyle (FMC), the lateral facet of the patello-femoral groove (LPG) and the medial tibial plateau (MTP). Cartilage stiffness (dynamic modulus, E(dyn)), as obtained with the ultrasound indentation instrument in situ, correlated highly linearly (r = 0.913, p < 0.01) with the values obtained using the reference material-testing device in vitro. Reproducibility (standardized coefficient of variation) of the ultrasound indentation measurements was 5.2%, 1.7% and 3.1% for E(dyn), ultrasound reflection coefficient of articular surface (R) and thickness, respectively. E(dyn) and R were site dependent (p