Functions of gelsolin: motility, signaling, apoptosis, cancer
Functions of gelsolin: motility, signaling, apoptosis, cancer
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DOI：
10.1016/s0955-0674(99)80012-x
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发表时间：
1999-02-01
影响因子：
7.5
通讯作者：
Kwiatkowski, DJ
中科院分区：
文献类型：
--
作者：
Kwiatkowski, DJ
在过去的一年里，已经发现了几个凝溶胶蛋白家族的新成员。凝溶胶蛋白的结构测定和溶血磷脂酸作为负调节剂的鉴定提供了新的功能见解。凝溶胶蛋白是Rac在真皮成纤维细胞中运动的专性下游效应物，在体内调节磷酸肌醇信号传导途径和离子通道功能，并且充当细胞凋亡的调节剂和效应物。
Several new members of the gelsolin family have been discovered in the past year. Determination of the structure of gelsolin and identification of lysophosphatidic acid as a negative regulator provide novel functional insights. Gelsolin is an obligate downstream effector of Rac for motility in dermal fibroblasts, regulates phosphoinositide signaling pathways and ion channel function in vivo, and acts as both a regulator and effector of apoptosis.