BEHAVIORAL-CHANGES FOLLOWING LESIONS OF THE ORBITAL PREFRONTAL CORTEX IN MALE-RATS
BEHAVIORAL-CHANGES FOLLOWING LESIONS OF THE ORBITAL PREFRONTAL CORTEX IN MALE-RATS
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DOI：
10.1016/0166-4328(83)90032-3
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发表时间：
1983-01-01
影响因子：
2.7
通讯作者：
VANDEPOLL, N
中科院分区：
文献类型：
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作者：
DEBRUIN, JPC;VANOYEN, HGM;VANDEPOLL, N
在3个不同年龄（30，45和60天）的雄性WEZOB大鼠的前额叶皮层（OF）的眶额部进行了双侧病变，并在成年期研究了行为变化。在测试的情况下，雄性间的侵略OF-病变的动物表现出更高的侵略水平比他们的控制操作的对手。这种变化没有看到在遇到雄性大鼠的侵略性较低的Wistar品系，强调了重要性的选择对手的测试中的激动行为。OF损伤不干扰男性性行为。当在一个开放的领域进行测试时，活动分数的OF-损伤的动物超过了对照组。与对照组相比，OF损伤导致术后2-3个月体重轻微但显著的长期减轻。然而，在手术后，没有观察到严重的摄食量减少（食欲不振），在所有3个年龄组中，攻击性和运动活动都有所增加，数据不支持30天手术与60天手术相比功能保留的假设。然而，在社会竞争的情况下，每个方法的alloroming回合的持续时间确实显示出一种模式，取决于病变的势头：青春期前的病变导致较不频繁的方法和梳理回合的持续时间较长。这些发现被解释为持续性的倾向，以下OF病变。
Bilateral lesions were made, confined to the orbitofrontal part of the prefrontal cortex (OF) of male WEZOB rats at 3 different ages (30, 45 and 60 days) and behavioural changes were studied in adulthood. In a test situation for intermale aggression OF-lesioned animals showed a higher level of aggression than their control-operated opponents. Such changes were not witnessed in encounters with male rats of the less aggressive Wistar strain which emphasizes the importance of the choice of the opponents in tests for agonistic behaviour. OF lesioning did not interfere with male sexual behaviour. When tested in an open field, activity scores of OF-lesioned animals exceeded those of the control group. OF lesioning resulted in a slight but significant long-term weight reduction, 2–3 months following surgery, in comparison with the control group. However, a severe reduction in food intake (aphagia), immediately after the operation, was not observed.Increase in both aggression and locomotor activity was seen in all 3 age groups, and data do not support the hypothesis that sparing of function had occurred in the 30-day operates, as compared with the 60-day operates. However, the duration of allogrooming bouts per approach in the social agonistic situation did show a pattern depending on the lesion momentum: prepubertal OF lesions resulting in less frequent approaches and grooming bouts of longer duration. These findings are explained in terms of perseverative tendencies following OF lesions.