Immunopathology of Behcet’s Disease: An Overview of the Metagenomic Approaches
Immunopathology of Behcet’s Disease: An Overview of the Metagenomic Approaches
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DOI：
10.3390/rheumato2030010
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发表时间：
2022-09
期刊：
影响因子：
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通讯作者：
J. Shimizu;Masanori A. Murayama;Y. Miyabe;N. Suzuki
中科院分区：
文献类型：
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作者：
J. Shimizu;Masanori A. Murayama;Y. Miyabe;N. Suzuki
居住在体内的微生物群对局部和全身免疫反应的影响已经越来越多地认识到。主要肠道微生物代谢产物短链脂肪酸（SCFAs）通过表观遗传修饰增强调节性T （Treg）细胞功能，在生理和病理状态下调节调节性T （Treg）细胞和辅助性T 17 （Th17）细胞之间的平衡。白塞氏病（BD）患者表现出Th17细胞介导的免疫反应增强，肠道中产生scfa细菌的相对丰度降低。意大利、荷兰、土耳其、中国和日本已经报道了BD患者异常免疫反应和肠道微生物组成之间的因果关系。我们报道了BD患者的肠道和口腔微生物群具有一些共同特征。针对共生微生物和致病微生物的免疫应答可能在BD的发展中起关键作用。本综述总结了1970-2022年期间从公共数据库（如PubMed和MEDLINE）检索到的关于BD患者免疫细胞和微生物群之间潜在功能相关性的文献，检索词包括Behcet病、辅助性T细胞和微生物群。
The impact of the microbiota residing in the body on local and systemic immune responses has been increasingly recognized. The major gut microbe metabolites’ short-chain fatty acids (SCFAs) are suggested to regulate the balance between regulatory (Treg) cells and helper T 17 (Th17) cells in physiological and pathological conditions by enhancing regulatory T (Treg) cell function through epigenetic modifications. Patients with Behcet’s disease (BD) exhibited enhanced Th17 cell-mediated immune responses and decreased intestinal relative abundances of SCFA-producing bacteria. Causal correlations between aberrant immune responses and gut microbial composition in patients with BD have been reported in Italy, the Netherlands, Turkey, China, and Japan. We reported that the gut and oral microbiota profiles of patients with BD shared some common features. Immune responses against both commensal and pathogenic microbes may play a crucial role in BD development. This review summarizes the current literature, which was retrieved from public databases, such as PubMed and MEDLINE using search terms, including Behcet’s disease, helper T cells, and microbiota, during 1970–2022, on the potential functional correlation between immune cells and microbiota in patients with BD.