THE PYLORIC CENTRAL PATTERN GENERATOR IN CRUSTACEA - A SET OF CONDITIONAL NEURONAL OSCILLATORS
THE PYLORIC CENTRAL PATTERN GENERATOR IN CRUSTACEA - A SET OF CONDITIONAL NEURONAL OSCILLATORS
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DOI：
10.1007/bf00604049
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发表时间：
1988-01-01
影响因子：
2.1
通讯作者：
MOULINS, M
中科院分区：
文献类型：
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作者：
BAL, T;NAGY, F;MOULINS, M
在开普龙虾（Jasus lalandii）的口胃神经系统中，构成幽门中枢模式发生器的所有神经元都是细胞振荡器。这是通过从幽门网络中的所有其他元件中原位分离幽门神经元来显示的。这些神经元振荡器是有条件的，需要来自前中枢的调节输入以表达其振荡能力。1.通过对大多数突触前神经元进行光灭活，将幽门神经元从网络中的对应物中分离出来（米勒and Selvertson 1979，1982 a），并通过对剩余突触前影响进行药物阻断来完成。在这些条件下，所有的幽门神经元显示自发爆发和潜在的振荡，他们的膜电位。2.所有离体幽门神经元的振荡周期和振幅的变化时，他们的膜电位被电流注入修改。此外，在离体缩窄神经元（LP，PY和IC）的节律性再生去极化的持续时间也依赖于膜电位。3.在原位分离后，每种类型的幽门神经元表现出特殊的振荡行为。孤立的中间神经元AB具有最快的振荡周期和最短的去极化相。这些振荡非常类似于完整网络中的AB振荡。在另一个极端是收缩神经元（LP，PY和IC），当孤立时，显示自发振荡，而在完整的网络中的振荡不同。幽门缩肌神经元的振荡是一个节律性的平台期，其持续时间和频率是相当不规则的。4.当轴突传导被阻断在单一的输入神经的口胃神经节，没有一个孤立的幽门神经元是能够振荡，无论是在休息时，或当他们的膜电位被修改电流注入。在这些条件下，电刺激神经节侧的输入神经块恢复孤立的幽门神经元的振荡。总之，幽门神经网络可以被认为是一组条件振荡神经元，其中之一，intreuron AB，具有起搏功能。
In the stomatogastric nervous system of the Cape lobster, Jasus lalandii, all the neurons comprising the pyloric central pattern generator are cellular oscillators. This was shown by isolating in situ pyloric neurons from all other elements in the pyloric network. These neuronal oscillators are conditional and require modulatory inputs from anterior centers in order to express their oscillatory capabilities. 1. Pyloric neurons were isolated from their counterparts in the network by photoinactivation of most of their presynaptic neurons (Miller and Selvertson 1979, 1982a), and completed by pharmacological blockade of the remaining presynaptic influences. Under these conditions, all pyloric neurons display spontaneous bursting and underlying oscillations of their membrane potential. 2. Both period and amplitude of oscillation in all isolated pyloric neurons vary when their membrane potential is modified by current injection. Furthermore, in isolated constrictor neurons (LP, PY and IC) the duration of the rhythmic regenerative depolarizations is also dependent on membrane potential. 3. After isolation in situ, each type of pyloric neuron manifests a particlar oscillatory behavior. The isolated interneuron AB has the fastest oscillation period with the shortest depolarizing phase. These oscillations closely resemble AB oscillations in the intact network. At the other extreme are the constrictor neurons (LP, PY and IC) which, when isolated, display spontaneous oscillations rather different from their oscillations in the intact network. Oscillations of pyloric constrictor neurons are rhythmical plateaus whose duration and frequency are fairly irregular. 4. When axonal conduction is blocked in the single input nerve to the stomatogastric ganglion, none of the isolated pyloric neurons is able to oscillate whether at rest or when their membrane potential is modified by current injection. Under these conditions, electrical stimulation of the input nerve on the ganglionic side of the block restores oscillations in isolated pyloric neurons. In conclusion, the pyloric network can be considered as a set of conditional oscillatory neurons, one of which, the intenreuron AB, has a pacemaker function.