Some treatments cause seizure aggravation in idiopathic epilepsies (especially absence epilepsy)
Some treatments cause seizure aggravation in idiopathic epilepsies (especially absence epilepsy)
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DOI：
10.1111/j.1528-1167.2009.02233.x
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发表时间：
2009-01-01
期刊：
影响因子：
5.6
通讯作者：
Somerville, Ernest R.
中科院分区：
文献类型：
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作者：
Somerville, Ernest R.
抗癫痫药物（AEDs）引起癫痫发作加重是一种罕见的现象，主要发生在全面性癫痫患者中，这些患者使用的药物对部分性癫痫发作更有效。它的频率被医生，尤其是病人大大高估了。还有许多其他原因癫痫发作恶化，但他们往往没有考虑。识别由aed引起的癫痫发作加重很重要，但同样重要的是不要过度诊断。通过准确的综合征诊断和使用对原发性全身性癫痫发作有效的药物治疗全身性癫痫，并避免无效的药物，可以在很大程度上预防该病。
P>Seizure aggravation by antiepileptic drugs (AEDs) is a rare phenomenon, occurring mostly in generalized epilepsies treated with drugs that are more efficacious against partial seizures. Its frequency is greatly overestimated by doctors and especially by patients. There are many other reasons for seizures to deteriorate but they are often not considered. Seizure aggravation by AEDs is important to recognize but equally important not to overdiagnose. It can largely be prevented by accurate syndromic diagnosis and the treatment of generalized epilepsies with drugs that are effective against primary generalized seizures and avoiding those that are not.