CALCIUM SUPPLEMENTATION REDUCES VERTEBRAL BONE LOSS IN PERIMENOPAUSAL WOMEN - A CONTROLLED TRIAL IN 248 WOMEN BETWEEN 46 AND 55 YEARS OF AGE
CALCIUM SUPPLEMENTATION REDUCES VERTEBRAL BONE LOSS IN PERIMENOPAUSAL WOMEN - A CONTROLLED TRIAL IN 248 WOMEN BETWEEN 46 AND 55 YEARS OF AGE
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DOI：
10.1210/jcem-73-3-533
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发表时间：
1991-09-01
影响因子：
5.8
通讯作者：
VANDERSTELT, PF
中科院分区：
文献类型：
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作者：
ELDERS, PJM;NETELENBOS, JC;VANDERSTELT, PF
为了研究钙补充剂对围绝经期骨丢失的影响，将295名妇女随机分为对照组和2个补充组，分别接受1000和2000 mg元素钙/天，为期2年。我们观察到与钙补充相关的腰椎骨丢失显著减少（对照组2年后平均损失3.5%，1000和2000 mg组分别为1.3%和0.7%），尿钙排泄显著增加，尿羟脯氨酸/肌酐比值、血清碱性磷酸酶、骨钙素和1，25-二羟维生素D补充钙对腰椎骨丢失的影响在补充钙的第一年是显著的，但在第二年则不显著。然而，在研究结束时，治疗组的尿羟脯氨酸/肌酐比值和血清碱性磷酸酶水平仍显著降低;血清骨钙素的情况并非如此。补充钙对掌骨皮质骨丢失没有显著影响。两个补充组之间的生化参数差异很小。在受试者的绝经状态和钙补充的效果之间没有观察到显著的相互作用。我们的结论是，补钙延缓腰椎骨丢失在第一年的补钙减少骨转换。然而，在较长的时间跨度内对腰椎骨丢失的影响仍然不确定。
To study the effect of calcium supplementation on perimenopausal bone loss, 295 women were randomized into a control group and 2 supplementation groups receiving, respectively, 1000 and 2000 mg elemental calcium/day for a period of 2 yr. We observed a significant decrease in lumbar bone loss in relation to the calcium supplementation (mean loss after 2 yr of 3.5% in the control group vs. 1.3% and 0.7% in the 1000 and 2000 mg groups, respectively), a significant increase in urinary calcium excretion, and a significant decrease in the urinary hydroxyproline/creatinine ratio, serum alkaline phosphatase, osteocalcin, and 1,25-dihydroxyvitamin D. The effect of calcium supplementation on lumbar bone loss was significant in the first year of supplementation, but not in the second. However, the urinary hydroxyproline/creatinine ratio and the serum alkaline phosphatase level remained significantly decreased in the treatment groups at the end of the study; this was not the case for serum osteocalcin. Calcium supplementation did not have a significant effect on metacarpal cortical bone loss. The difference in biochemical parameters between the 2 supplementation groups was small. No significant interaction was observed between the menopausal status of the subjects and the effect of calcium supplementation. We conclude that calcium supplementation retards lumbar bone loss in the first year of calcium supplementation by reducing bone turnover. However, the effect on lumbar bone loss over a longer time span is still uncertain.