Velopharyngeal Insufficiency Clinic: The First 18 Months
Velopharyngeal Insufficiency Clinic: The First 18 Months
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DOI：
10.2310/7070.2008.0112
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发表时间：
2008-08-01
影响因子：
3.4
通讯作者：
Dworschak-Stokan, Anne
中科院分区：
文献类型：
--
作者：
Hamilton, Scott;Husein, Murad;Dworschak-Stokan, Anne
目的：描述在腭咽闭合不全（VPI）诊所就诊的患者的表现和管理，并探讨VPI检查中常用调查的作用。设计：回顾性分析。设置：三级护理VPI诊所。方法：访问在患者评估时创建的计算机化数据库，以回顾18个月跨度内就诊的75例患者。主要结果测量：患者人口统计学、主诉、病理生理学和治疗的描述性分析。染色体22 q微缺失的发病率在这样一个clinic.Results：最常见的病因是持续性VPI之前腭裂手术后的患者提出的。11%的患者被确定与22 q微缺失荧光原位杂交testing.Conclusions：VPI是一个广泛的病因的结果，与22 q微缺失的高发病率确定。建议在VPI诊所进行常规基因检测。
Objectives: To profile the presentation and management of patients seen at a velopharyngeal insufficiency (VPI) clinic and to explore the role of commonly used investigations in the workup of VPI.Design: Retrospective review.Setting: Tertiary care VPI clinic.Methods: A computerized database created at the time of patient assessment was accessed to review 75 patients seen over an 18-month span.Main Outcome Measures: Descriptive analysis of patient demographics, presenting complaints, pathophysiology, and treatment. The incidence of chromosome 22q microdeletion in patients presenting to such a clinic was also determined.Results: The most common etiology was persistent VPI following prior cleft palate surgery. Eleven percent of presenting patients were identified with 22q microdeletion by fluorescent in situ hybridization testing.Conclusions: VPI is the result of a wide number of etiologies, with a high incidence of 22q microdeletion identified. Routine genetic testing in VPI clinics is advocated.