A structural and functional perspective of alphavirus replication and assembly.
A structural and functional perspective of alphavirus replication and assembly.
复制标题
DOI：
10.2217/fmb.09.59
复制
发表时间：
2009-09
影响因子：
3.1
通讯作者：
Kuhn RJ
中科院分区：
文献类型：
--
作者：
Jose J;Snyder JE;Kuhn RJ
甲病毒是一种小的、球形的、有包膜的正义ssRNA病毒，引起相当多的人类和动物疾病。甲病毒属成员包括基孔肯雅病毒、辛德毕斯病毒、塞姆利基森林病毒、西部、东部和委内瑞拉马脑炎病毒以及罗斯河病毒。甲病毒可在人类和动物中引起关节炎疾病和脑炎，并继续成为世界范围的威胁。病毒通过吸血节肢动物传播，并在节肢动物和脊椎动物宿主中复制。甲病毒形成球形颗粒（直径65-70 nm），具有二十面体对称性和四个三角形数。甲病毒的二十面体结构已经通过冷冻电子显微镜和晶体学研究被定义为非常高的分辨率。本文综述了甲病毒感染过程中的主要事件：进入、复制、组装和出芽。我们专注于从甲病毒的结构和功能研究中获得的数据。这些结构和功能数据为病毒生命周期和结构提供了更广阔的视角，并允许对这些重要病毒进行额外的洞察。
Alphaviruses are small, spherical, enveloped, positive-sense ssRNA viruses responsible for a considerable number of human and animal diseases. Alphavirus members include Chikungunya virus, Sindbis virus, Semliki Forest virus, the western, eastern and Venezuelan equine encephalitis viruses, and the Ross River virus. Alphaviruses can cause arthritic diseases and encephalitis in humans and animals and continue to be a worldwide threat. The viruses are transmitted by blood-sucking arthropods, and replicate in both arthropod and vertebrate hosts. Alphaviruses form spherical particles (65–70 nm in diameter) with icosahedral symmetry and a triangulation number of four. The icosahedral structures of alphaviruses have been defined to very high resolutions by cryo-electron microscopy and crystallographic studies. In this review, we summarize the major events in alphavirus infection: entry, replication, assembly and budding. We focus on data acquired from structural and functional studies of the alphaviruses. These structural and functional data provide a broader perspective of the virus lifecycle and structure, and allow additional insight into these important viruses.
登录
查看更多内容
影响因子：
3.7
作者：
Bear, JS;Byrnes, AP;Griffin, DE
通讯作者：
Griffin, DE
影响因子：
3.7
作者：
Ferreira, D;Hernandez, R;Brown, DT
通讯作者：
Brown, DT
影响因子：
3.7
作者：
DAVIS, NL;PENCE, DF;JOHNSTON, RE
通讯作者：
JOHNSTON, RE
影响因子：
5.4
作者：
FLYNN, DC;MEYER, WJ;JOHNSTON, RE
通讯作者：
JOHNSTON, RE
影响因子：
5.4
作者：
Ahn, A;Klimjack, MR;Kielian, M
通讯作者：
Kielian, M