EFFECT OF CENTRALLY ADMINISTERED NEUROTENSIN ON MULTIPLE FEEDING PARADIGMS
EFFECT OF CENTRALLY ADMINISTERED NEUROTENSIN ON MULTIPLE FEEDING PARADIGMS
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DOI：
10.1016/0091-3057(83)90244-7
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发表时间：
1983-01-01
影响因子：
3.6
通讯作者：
MORLEY, JE
中科院分区：
文献类型：
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作者：
LEVINE, AS;KNEIP, J;MORLEY, JE
十三肽神经降压素可能是一种内源性饱腹感因子。研究了神经降压素对已知刺激进食的多种范式的影响。在30小时饥饿期后，与盐水对照相比，神经降压素在20 μ g和10 μ g剂量下抑制摄食，但在1 μ g剂量下不抑制摄食。去甲肾上腺素[NE]（20 μ g i. c. v.[脑室内]）诱导的摄食在20 μ g神经降压素剂量下受到抑制，但在10 μ g或1 μ g剂量下不受抑制。在任何剂量下，神经降压素都不能抑制蝇蕈醇诱导的摄食。胰岛素诱导进食（10单位s.c.）也不受神经紧张的抑制。神经降压素在20 μ g和10 μ g剂量下抑制强啡肽诱导的摄食，但在1 μ g剂量下不抑制。神经降压素抑制迷走神经切断大鼠的自发摄食（P < 0.01）（2.5 ± 0.01）。0.3 g/2h）。0.5 g/2 h），提示迷走神经的完整性不是神经紧张素的降压作用所必需的。神经降压素可能通过与单胺和神经肽的复杂相互作用在短期食欲调节中发挥作用;特别是NE和κ阿片激动剂强啡肽。
The tridecapeptide, neurotensin, may be an endogenous satiety factor. The effects of neurotensin on multiple paradigms known to stimulate feeding were studied. Following a 30 h starvation period, neurotensin suppressed feeding at the 20 .mu.g and 10 .mu.g dose, but not at the 1 .mu.g dose when compared to saline controls. Norepinephrine [NE] (20 .mu.g i.c.v. [intracerebroventricular]) induced feeding was suppressed at the 20 .mu.g neurotensin dose but not at the 10 .mu.g or 1 .mu.g dose. Neurotensin did not suppress muscimol induced feeding at any of the doses. Insulin induced feeding (10 units s.c.) also was not suppressed by neurotension. Neurotensin suppressed dynorphin induced feeding at the 20 .mu.g and 10 .mu.g but not at the 1 .mu.g dose. Neurotensin suppressed spontaneous feeding (P < 0.01) in vagotomized rats (2.5 .+-. 0.3 g/2 h) when compared with saline controls (4.2 .+-. 0.5 g/2 h) suggesting that an intact vagus is not necessary for neurotensin''s anoretic effect. Neurotensin may play a role in short-term appetite regulation by a complex interaction with monoamines and neuropeptides; particularly NE and the kappa opiate agonist, dynorphin.