Synergistic damage by UVA radiation and pollutants
Synergistic damage by UVA radiation and pollutants
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DOI：
10.1177/0748233709106067
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发表时间：
2009-05-01
影响因子：
1.9
通讯作者：
Wei, H.
中科院分区：
文献类型：
--
作者：
Burke, K. E.;Wei, H.
皮肤癌不仅是迄今为止最常见的人类癌症，而且近几十年来皮肤癌的发病率以惊人的速度增加。幸运的是，大多数人现在意识到阳光照射会导致不美观的光老化和皮肤癌，因此他们确实认真涂抹防晒霜。然而，直到最近，大多数防晒霜都无法充分防护紫外线 A (UVA) 辐射。虽然 UVA 确实比 UVB 的致红性和致癌性更低，但 UVA 直接导致光老化并增强 UVB 诱发的皮肤癌。此外，最近的研究表明，UVA 与环境污染物（包括香烟烟雾）结合会显着增加患皮肤癌的风险。同样，之前的研究证明了环境污染物和紫外线之间的另一种协同作用：当臭氧暴露先于紫外线暴露时，紫外线引起的皮肤角质层保护性维生素 E 的消耗会增加。本文回顾了环境污染物（例如苯并[a]芘 (BaP)，一种常用的环境污染指标）是光敏剂的实验证据，当暴露于 UVA 辐射时会产生活性氧 (ROS)。这反过来会导致氧化和遗传损伤，导致不美观的光损伤和致癌作用。毒理学与工业健康2009； 25：219-224。
Not only is skin cancer by far the most common human cancer but also the incidence of skin cancer has been increasing at an alarming rate in recent decades. Fortunately, most people now realize that sun exposure causes unattractive photoaging and skin cancer, so they do apply sunscreens conscientiously. However, until recently, most sunscreens did not adequately protect against ultraviolet A (UVA) radiation. Although UVA is indeed less erythrogenic and less carcinogenic than UVB, UVA directly causes photoaging and enhances UVB-induced skin cancer. Furthermore, recent research demonstrates that UVA combined with environmental pollutants (including cigarette smoke) significantly increases the risk of skin cancer. Similarly, previous research demonstrated another synergy between environmental pollutants and UV: When ozone exposure precedes UV exposure, there is enhancement of UV-induced depletion of protective vitamin E from the skin's stratum corneum. This article reviews experimental evidence that environmental pollutants (such as benzo[a] pyrene (BaP), a commonly used index of environmental pollution) are photosensitizers that generate reactive oxygen species (ROS) when exposed to UVA radiation. This in turn causes oxidative and genetic damage, leading to unattractive photodamage and carcinogenesis. Toxicology and Industrial Health 2009; 25: 219-224.