Kisspeptin in the Prediction of Pregnancy Complications.
Kisspeptin in the Prediction of Pregnancy Complications.
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DOI：
10.3389/fendo.2022.942664
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发表时间：
2022
影响因子：
5.2
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中科院分区：
文献类型：
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Kisspeptin及其受体作为人类生殖内分泌轴的关键调节因子，对生殖健康至关重要。Kisspeptin被广泛认为是促性腺激素释放激素（GnRH）神经元功能的调节剂。然而，最近的证据表明，kisspeptin及其受体也发挥了重要作用，在怀孕期间的调节胎盘。Kisspeptin在合体滋养细胞中大量表达，其受体在细胞滋养细胞和合体滋养细胞中均表达。在健康妊娠期间，Kisspeptin的循环水平急剧上升，已被提出作为胎盘功能的生物标志物。事实上，kisspeptin水平的改变与母体和胎儿不良并发症的风险增加有关。本综述总结了评估kisspeptin作为妊娠并发症（包括流产、异位妊娠（EP）、早产（PTB）、胎儿生长受限（FGR）、妊娠期高血压疾病（HDP）、先兆子痫（PE）、妊娠期糖尿病（GDM）和妊娠滋养细胞疾病（GTD））的假定生物标志物的作用的数据。
Kisspeptin and its receptor are central to reproductive health acting as key regulators of the reproductive endocrine axis in humans. Kisspeptin is most widely recognised as a regulator of gonadotrophin releasing hormone (GnRH) neuronal function. However, recent evidence has demonstrated that kisspeptin and its receptor also play a fundamental role during pregnancy in the regulation of placentation. Kisspeptin is abundantly expressed in syncytiotrophoblasts, and its receptor in both cyto- and syncytio-trophoblasts. Circulating levels of kisspeptin rise dramatically during healthy pregnancy, which have been proposed as having potential as a biomarker of placental function. Indeed, alterations in kisspeptin levels are associated with an increased risk of adverse maternal and foetal complications. This review summarises data evaluating kisspeptin’s role as a putative biomarker of pregnancy complications including miscarriage, ectopic pregnancy (EP), preterm birth (PTB), foetal growth restriction (FGR), hypertensive disorders of pregnancy (HDP), pre-eclampsia (PE), gestational diabetes mellitus (GDM), and gestational trophoblastic disease (GTD).