Prefrontal cortex involvement in preattentive auditory deviance detection:: neuroimaging and electrophysiological evidence
Prefrontal cortex involvement in preattentive auditory deviance detection:: neuroimaging and electrophysiological evidence
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DOI：
10.1016/s1053-8119(03)00389-6
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发表时间：
2003-10-01
期刊：
影响因子：
5.7
通讯作者：
Schröger, E
中科院分区：
文献类型：
--
作者：
Doeller, CF;Opitz, B;Schröger, E
以往的电生理和神经影像学研究表明，失配负波（MMN）是由颞额神经网络产生的，有助于前注意听觉变化检测。在两个实验中，我们采用事件相关脑电位（ERP）和事件相关功能磁共振成像（fMRI）检查神经和血流动力学活动的异常处理，使用三种类型的异常音（小，中，大）在音高和空间条件。在俯仰条件下，右侧上级颞回（STG）的血流动力学活动作为偏离的函数增加。小和中等和小和大的偏差之间的比较显示，右额前额叶激活额下回（IFG; BA 44/45）和额中回（MFG; BA 46），而相对于中等偏大导致左和右IFG（BA 44/45）激活。在ERP实验中，早期MMN（90-120 ms）的幅度作为偏差的函数增加，通过这与fMRI实验中的右STG激活平行。MMN振幅和偏离程度之间的U形关系，观察到在一个晚的时间窗口（140-170 ms）类似的权利IFG激活模式。在随后的源分析的fMRI激活灶的约束下，早期和晚期MMN活动可以模拟偶极子放置在STG和IFG，分别。在空间条件下，未观察到可靠的血流动力学激活。在ERP实验中，所有三个空间偏差的MMN幅度都比在音高条件下小得多。与音高条件相反，它在早期和晚期时间窗口中作为偏差的函数增加。我们认为，正确的IFG介导的听觉偏差检测的情况下，感官记忆痕迹和听觉输入之间的低辨别力。这种前额叶机制可能是STG异常检测系统自上而下调制的一部分。(C)2003年爱思唯尔公司保留所有权利。
Previous electrophysiological and neuroimaging studies suggest that the mismatch negativity (MMN) is generated by a temporofrontal network subserving preattentive auditory change detection. In two experiments we employed event-related brain potentials (ERP) and event-related functional magnetic resonance imaging (fMRI) to examine neural and hemodynamic activity related to deviance processing, using three types of deviant tones (small, medium, and large) in both a pitch and a space condition. In the pitch condition, hemodynamic activity in the right superior temporal gyrus (STG) increased as a function of deviance. Comparisons between small and medium and between small and large deviants revealed right prefrontal activation in the inferior frontal gyrus (IFG; BA 44/45) and middle frontal gyrus (MFG; BA 46), whereas large relative to medium deviants led to left and right IFG (BA 44/45) activation. In the ERP experiment the amplitude of the early MMN (90-120 ms) increased as a function of deviance, by this paralleling the right STG activation in the fMRI experiment. A U-shaped relationship between MMN amplitude and the degree of deviance was observed in a late time window (140-170 ms) resembling the right IFG activation pattern. In a subsequent source analysis constrained by fMRI activation foci, early and late MMN activity could be modeled by dipoles placed in the STG and IFG, respectively. In the spatial condition no reliable hemodynamic activation could be observed. The MMN amplitude was substantially smaller than in the pitch condition for all three spatial deviants in the ERP experiment. In contrast to the pitch condition it increased as a function of deviance in the early and in the late time window. We argue that the right IFG mediates auditory deviance detection in case of low discriminability between a sensory memory trace and auditory input. This prefrontal mechanism might be part of top-down modulation of the deviance detection system in the STG. (C) 2003 Elsevier Inc. Ail rights reserved.