Cancer stem cells: mirage or reality?
Cancer stem cells: mirage or reality?
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DOI：
10.1038/nm0909-1010
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发表时间：
2009-09-01
期刊：
影响因子：
82.9
通讯作者：
Weinberg, Robert A.
中科院分区：
文献类型：
--
作者：
Gupta, Piyush B.;Chaffer, Christine L.;Weinberg, Robert A.
正常组织干细胞和癌症干细胞（CSCs）之间的相似性和差异性一直是争论的根源，最近的一些研究对CSCs的存在提出了质疑。然而，对文献的检查表明，CSC模型依赖于坚实的实验基础，并且肿瘤内观察到的CSC频率的差异反映了用于测定这些细胞的各种癌症类型和宿主。对干细胞和称为上皮-间充质转化（EMT）的分化程序的研究指出干细胞与其更分化的衍生物之间可能存在可塑性。如果存在，这种可塑性将对CSC模型和未来的治疗方法产生重大影响。
The similarities and differences between normal tissue stem cells and cancer stem cells (CSCs) have been the source of much contention, with some recent studies calling into question the very existence of CSCs. An examination of the literature indicates, however, that the CSC model rests on firm experimental foundations and that differences in the observed frequencies of CSCs within tumors reflect the various cancer types and hosts used to assay these cells. Studies of stem cells and the differentiation program termed the epithelial-mesenchymal transition (EMT) point to the possible existence of plasticity between stem cells and their more differentiated derivatives. If present, such plasticity would have major implications for the CSC model and for future therapeutic approaches.