A model-based systems approach to pharmaceutical product-process design and analysis
A model-based systems approach to pharmaceutical product-process design and analysis
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DOI：
10.1016/j.ces.2010.05.003
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发表时间：
2010-11-01
影响因子：
4.7
通讯作者：
Gani, Rafiqul
中科院分区：
文献类型：
--
作者：
Gernaey, Krist V.;Gani, Rafiqul
这是一个透视文件强调需要系统的基于模型的设计和分析，在制药产品工艺开发。一个基于模型的框架，并讨论了各种类型的模型的作用，开发和使用的产品和过程的模型的结构。需要一个系统的建模框架，强调与模型识别，适应和扩展有关的建模问题。在产品设计与分析领域，预测模型的应用范围非常广泛。在过程综合和设计领域，突出了使用通用过程模型，从该模型可以生成特定的过程模型。使用多尺度建模方法来扩展属性模型的应用范围也是突出的。不同类型的过程模型，模型分析和模型生成的例子。(C)2010爱思唯尔有限公司保留所有权利。
This is a perspective paper highlighting the need for systematic model-based design and analysis in pharmaceutical product-process development. A model-based framework is presented and the role, development and use of models of various types are discussed together with the structure of the models for the product and the process. The need for a systematic modelling framework is highlighted together with modelling issues related to model identification, adaptation and extension. In the area of product design and analysis, predictive models are needed with a wide application range. In the area of process synthesis and design, the use of generic process models from which specific process models can be generated, is highlighted. The use of a multi-scale modelling approach to extend the application range of the property models is highlighted as well. Examples of different types of process models, model analysis and model generation are presented. (C) 2010 Elsevier Ltd. All rights reserved.