Th17 Cell Plasticity and Functions in Cancer Immunity.
Th17 Cell Plasticity and Functions in Cancer Immunity.
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DOI：
10.1155/2015/314620
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发表时间：
2015
影响因子：
--
通讯作者：
Hugues S
中科院分区：
文献类型：
--
作者：
Guéry L;Hugues S
Th 17细胞代表辅助性T淋巴细胞的特定亚群，其特征在于高产生IL-17和其它炎性细胞因子。Th 17细胞参与粘膜和上皮屏障的抗微生物免疫，特别是对抗细胞外细菌和真菌。虽然Th 17细胞在促进炎症和自身免疫性疾病中的作用已被广泛和优雅地证明，但Th 17细胞是否以及如何影响肿瘤免疫仍然存在争议。虽然与健康组织相比，Th 17细胞特异性地在许多不同类型的肿瘤中积累，但结果可能因肿瘤类型而异。因此，Th 17细胞与好的和坏的肿瘤都相关。这些细胞对表现出抗炎或相反致病功能的细胞的高可塑性可能有助于Th 17在肿瘤背景下的多功能。一方面，Th 17细胞通过诱导血管生成（通过IL-17）和通过发挥自身免疫抑制功能来促进肿瘤生长。另一方面，Th 17细胞通过将免疫细胞募集到肿瘤中、激活效应CD 8 + T细胞或甚至直接通过向Th 1表型转化并产生IFN-γ来驱动抗肿瘤免疫应答。在这篇综述中，我们讨论了肿瘤微环境对Th 17细胞可塑性和功能的影响及其在癌症免疫中的意义。
Th17 cells represent a particular subset of T helper lymphocytes characterized by high production of IL-17 and other inflammatory cytokines. Th17 cells participate in antimicrobial immunity at mucosal and epithelial barriers and particularly fight against extracellular bacteria and fungi. While a role for Th17 cells in promoting inflammation and autoimmune disorders has been extensively and elegantly demonstrated, it is still controversial whether and how Th17 cells influence tumor immunity. Although Th17 cells specifically accumulate in many different types of tumors compared to healthy tissues, the outcome might however differ from a tumor type to another. Th17 cells were consequently associated with both good and bad prognoses. The high plasticity of those cells toward cells exhibiting either anti-inflammatory or in contrast pathogenic functions might contribute to Th17 versatile functions in the tumor context. On one hand, Th17 cells promote tumor growth by inducing angiogenesis (via IL-17) and by exerting themselves immunosuppressive functions. On the other hand, Th17 cells drive antitumor immune responses by recruiting immune cells into tumors, activating effector CD8+ T cells, or even directly by converting toward Th1 phenotype and producing IFN-γ. In this review, we are discussing the impact of the tumor microenvironment on Th17 cell plasticity and function and its implications in cancer immunity.