Oral rehydration therapy: an epithelial transport success story.
Oral rehydration therapy: an epithelial transport success story.
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口服补液疗法：上皮运输的成功故事。
DOI：
--
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发表时间：
1989
影响因子：
5.2
通讯作者：
W. Greenough
中科院分区：
文献类型：
--
作者：
W. Greenough
口服补液疗法可预防急性水样腹泻导致的死亡，但最严重的 1-3% 霍乱病例除外。贫穷国家迅速扩大了这种治疗的使用，而富裕国家则使用更危险的住院治疗和静脉注射治疗。补液疗法起源于家庭或民间疗法；不幸的是，它们的构成往往不足以预防死亡或在没有高渗或低渗危险的情况下发挥作用。随后，当将具有明确组成边界的口胃葡萄糖电解质溶液给予霍乱患者时，结果表明口服溶液可以成功地再水合并维持水合作用。这种由经过短期培训的志愿者进行的治疗将加尔各答的死亡率降至 3% 以下，而在有医疗监督且使用静脉输液治疗最严重病例的地方，死亡率低于 1%。由于除了饥荒之外，大多数家庭都有谷物和盐作为解决方案，根据现有知识，急性水样腹泻造成的死亡应该很少。通过研究和技术，可以生产新的聚合物溶液并以低成本方便地包装，以帮助发展中国家和发达国家使用口服补液疗法治疗腹泻。
Oral rehydration therapy prevents death from acute watery diarrhea except in the most severe 1-3% of cholera cases. Poor countries have rapidly expanded their use of this treatment while wealthy nations use more hazardous hospitalization and intravenous therapy. The origin of rehydration treatment was from home or folk remedies; unfortunately they were often not constituted adequately to prevent deaths or to be effective without the hazards of hypertonicity or hypotonicity. Subsequently when orogastric glucose-electrolyte solutions with well defined boundaries of composition were administered to cholera patients it was shown that oral solution could successfully rehydrate and maintain hydration. This treatment administered by briefly trained volunteers dropped the death rate to less than 3% in Calcutta and where there was medical supervision and intravenous fluid was used for the most severe cases mortality was less than 1%. Since most households have cereals and salt for solutions except in famine conditions with the communication of present knowledge there should be few deaths due to acute watery diarrhea. Through research and technology new polymeric solutions can be produced and conveniently packaged at low cost to aid developing as well as developed countries in the use of oral rehydration therapy for diarrhea.
实验性渗透性腹泻中的口服水合溶液：通过丙氨酸和其他氨基酸和寡肽增强。
DOI：
10.1093/ajcn/48.1.84
发表时间：
1988
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Wapnir,RA;Zdanowicz,MM;Teichberg,S;Lifshitz,F
通讯作者：
Lifshitz,F
大豆基、无乳糖配方奶粉在治疗急性腹泻中的作用。
影响因子：
8
作者：
Santosham,M;Foster,S;Reid,R;Bertrando,R;Yolken,R;Burns,B;Sack,RB
通讯作者：
Sack,RB