The amygdalostriatal and corticostriatal effective connectivity in anticipation and evaluation of facial attractiveness
The amygdalostriatal and corticostriatal effective connectivity in anticipation and evaluation of facial attractiveness
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DOI：
10.1016/j.bandc.2013.04.011
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发表时间：
2013-08
影响因子：
2.5
通讯作者：
Hongbo Yu;Zhiheng Zhou;Xiaolin Zhou
中科院分区：
文献类型：
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作者：
Hongbo Yu;Zhiheng Zhou;Xiaolin Zhou
决策过程包括信息处理的几个阶段，包括预测阶段和结果评估阶段。先前的研究表明，腹侧纹状体（VS）是这两个阶段的关键，桥接动机和行动，它与腹侧内侧前额叶皮层（vmPFC）和杏仁核协同工作。然而，关于VS如何与VMPFC和杏仁核一起工作的证据主要来自神经病理学和动物研究;对这个网络在人脑功能中的动态知之甚少。本研究采用功能磁共振成像结合动态因果模型（DCM）的方法，研究了面孔吸引力猜测任务中沿着杏仁纹状体和皮质纹状体通路的信息流。具体来说，我们要求参与者猜测女性脸部的模糊照片是否有吸引力，并等待几秒钟（“预期阶段”），直到呈现出一张未模糊的反馈脸部照片，无论是有吸引力还是没有吸引力（“结果评估阶段”）。在预测阶段，双侧杏仁核和VS对“有吸引力”的猜测比对“没有吸引力”的猜测表现出更高的激活。在结果评价阶段，vmPFC和双边VS被激活的反馈面孔，其吸引力是一致的初始猜测比不一致的面孔，但这种效果只对有吸引力的面孔，而不是没有吸引力的。DCM显示，在预期阶段，选择相关信息通过杏仁核进入杏仁-纹状体通路，投射到VS;在评价阶段，结果相关信息通过vmPFC进入皮质-纹状体通路。VMPFC和VS之间存在双向连接，VS到VMPFC的连接被不吸引人的面孔削弱。这些发现展示了在决策的不同阶段，信息流沿着杏仁体纹状体和皮质纹状体通路的模式，从而推进了我们对奖赏回路的理解。
Decision-making consists of several stages of information processing, including an anticipation stage and an outcome evaluation stage. Previous studies showed that the ventral striatum (VS) is pivotal to both stages, bridging motivation and action, and it works in concert with the ventral medial prefrontal cortex (vmPFC) and the amygdala. However, evidence concerning how the VS works together with the vmPFC and the amygdala came mainly from neuropathology and animal studies; little is known about the dynamics of this network in the functioning human brain. Here we used fMRI combined with dynamic causal modeling (DCM) to investigate the information flow along amygdalostriatal and corticostriatal pathways in a facial attractiveness guessing task. Specifically, we asked participants to guess whether a blurred photo of female face was attractive and to wait for a few seconds (“anticipation stage”) until an unblurred photo of feedback face, which was either attractive or unattractive, was presented (“outcome evaluation stage”). At the anticipation stage, the bilateral amygdala and VS showed higher activation for the “attractive” than for the “unattractive” guess. At the outcome evaluation stage, the vmPFC and the bilateral VS were more activated by feedback faces whose attractiveness was congruent with the initial guess than by incongruent faces; however, this effect was only significant for attractive faces, not for unattractive ones. DCM showed that at the anticipation stage, the choice-related information entered the amygdalostriatal pathway through the amygdala and was projected to the VS. At the evaluation stage, the outcome-related information entered the corticostriatal pathway through the vmPFC. Bidirectional connectivities existed between the vmPFC and VS, with the VS-to-vmPFC connectivity weakened by unattractive faces. These findings advanced our understanding of the reward circuitry by demonstrating the pattern of information flow along the amygdalostriatal and corticostriatal pathways at different stages of decision-making.