Carbon-11-labeled methylated polyamine analogs: uptake in prostate and tumor in animal models.
Carbon-11-labeled methylated polyamine analogs: uptake in prostate and tumor in animal models.
复制标题
碳 11 标记的甲基化多胺类似物：动物模型中前列腺和肿瘤的摄取。
作者：
M. Welch;R. Coleman;M. Straatmann;B. E. Asberry;J. L. Primeau;W. Fair;M. Ter
多胺腐胺、精胺和亚精胺通过添加碳-11标记的甲醛和硼氢化钠进行甲基化。高标记产生WIRBON-11标记的甲醛，然后是硼氢化钠。通过简单的煮沸溶液，获得了高的标记率和最终产物的纯化。这分解了多余的硼氢化钠，并去除了挥发性杂质。所有甲基化化合物的最终放化纯度均在85%以上。三种甲基化化合物均在雄性大鼠前列腺中积累，N-甲基-1，4-二氨基丁烷(腐胺类似物)的分布与氚腐胺的分布非常相似。腐胺类似物在前列腺和小鼠肿瘤中的摄取略高于所研究的其他两种类似物。利用正电子横轴断层扫描仪和腐胺类似物，我们已经能够对狗的前列腺进行成像。
The polyamines putrescine, spermine, and spermidine were methylated by the addition of carbon-11-labeled formaledehyde followed by sodium borohydride. High labeling yields wrbon-11-labeled formaldehyde followed by sodium borohydride. High labeling yields were obtained and the final products were purified by simply boiling the solution. This decomposed the excess sodium borohydride and removed the volatile impurities. The final radiochemical purity of all the methylated compounds was above 85%. All three methyltated compounds accumulated in the prostates of male rats and the distribution of N-methyl-1,4-diaminobutane (the putrescine analog) was very similar to that previously obtained with tritiated putrescine. The uptake of the putrescine analog in both the prostate and in mouse tumor was slightly higher than that obtained with the other two analogs studied. Utilizing a positron transaxial tomographic scanner and the putrescine analog, we have been able to image the prostate gland of a dog.