Carotid Artery Wall Thickness and Incident Cardiovascular Events: A Comparison between US and MRI in the Multi-Ethnic Study of Atherosclerosis (MESA).
Carotid Artery Wall Thickness and Incident Cardiovascular Events: A Comparison between US and MRI in the Multi-Ethnic Study of Atherosclerosis (MESA).
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DOI：
10.1148/radiol.2018173069
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发表时间：
2018-10
期刊：
影响因子：
19.7
通讯作者：
Yiyi Zhang;E. Guallar;S. Malhotra;B. Astor;J. Polak;Y. Qiao;A. Gomes;D. Herrington;A. Sharrett;D. Bluemke;B. Wasserman
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文献类型：
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作者：
Yiyi Zhang;E. Guallar;S. Malhotra;B. Astor;J. Polak;Y. Qiao;A. Gomes;D. Herrington;A. Sharrett;D. Bluemke;B. Wasserman
目的比较超声和MRI半自动测量颈总动脉(CCA)壁厚度，探讨其与冠心病、卒中发病的关系。材料和方法这项前瞻性研究从2000年7月至2013年12月在多民族动脉粥样硬化研究(MESA)中招募了698名无临床心血管疾病(CVD)病史的参与者(平均年龄63岁；年龄范围45~84岁；男性和女性相同)。所有参与者都提供了书面知情同意。颈总动脉壁厚度由超声、平扫质子密度加权和静脉注射Gd增强MRI测量。使用COX比例风险模型评估超声和MRI测量的室壁厚度与心血管疾病预后之间的关系。结果调整后的冠心病、中风和心血管疾病的危险比分别为1.10、1.08和1.14。质子密度加权MRI测量的平均壁厚的相应关联度为1.32、1.48和1.37，而增强Gd的MRI测量的平均壁厚的对应关联度为1.27、1.58和1.38。当同时包括在同一模型中时，MRI壁厚度，而不是内中膜厚度，仍然与预后相关。结论对于基线水平无已知心血管疾病的个体，MRI测量的室壁厚度与心血管疾病，特别是卒中的相关性比超声测量的内中膜厚度更一致。©RSNA，2018在线补充材料可供本文使用。
Purpose To compare common carotid artery (CCA) wall thickness measured manually by using US and semiautomatically by using MRI, and to examine their associations with incident coronary heart disease and stroke. Materials and Methods This prospective study enrolled 698 participants without a history of clinical cardiovascular disease (CVD) from the Multi-Ethnic Study of Atherosclerosis (MESA) from July 2000 to December 2013 (mean age, 63 years; range, 45 to 84 years; same for men and women). All participants provided written informed consent. CCA wall thickness was measured with US as well as both noncontrast proton-density-weighted and intravenous gadolinium-enhanced MRI. Cox proportional hazards models were used to assess the associations between wall thickness measurements by using US and MRI with CVD outcomes. Results The adjusted hazard ratios for coronary heart disease, stroke, and CVD associated with per standard deviation increase in intima-media thickness were 1.10, 1.08, and 1.14, respectively. The corresponding associations for mean wall thickness measured with proton-density-weighted MRI were 1.32, 1.48, and 1.37, and for mean wall thickness measured with gadolinium-enhanced MRI were 1.27, 1.58, and 1.38. When included simultaneously in the same model, MRI wall thickness, but not intima-media thickness, remained associated with outcomes. Conclusion For individuals without known cardiovascular disease at baseline, wall thickness measurements by using MRI were more consistently associated with incident cardiovascular disease, particularly stroke, than were intima-media thickness by using US. © RSNA, 2018 Online supplemental material is available for this article.