Application of liquid-based preparation to fine needle aspiration cytology in breast cancer
Application of liquid-based preparation to fine needle aspiration cytology in breast cancer
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DOI：
10.1159/000325603
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发表时间：
2008-09-01
期刊：
影响因子：
1.8
通讯作者：
Nemoto, Norimichi
中科院分区：
文献类型：
--
作者：
Komatsu, Kyoko;Nakanishi, Yoko;Nemoto, Norimichi
目的探讨液基细胞学（liquid-based cytology，LBC）在乳腺癌细胞学诊断中的应用价值，研究设计采用直接从手术切除的乳腺肿块中刮取的细胞团，对标本进行免疫细胞化学、分子生物学和细胞形态学检查。LBC的细胞学特征略有不同，从传统的抽吸细胞学涂片。ConclusionLBC是一个很有前途的方法，提高标准化的准备工作，在乳腺细胞学，但应注意考虑到其特有的细胞学特征。HER-2 mRNA定量分析与免疫组化结果相关。
ObjectiveTo examine the performance of liquid-based cytology (LBC) in breast cytology to confirm the diagnosis of carcinoma.Study DesignUsing cell clusters directly scratched from surgically removed tumor masses, we examined the immunocytochemistry, molecular biology and cytomorphology of the specimens.ResultsLBC was very useful for gene analysis and evaluating the immunocytochemistry. The cytologic features of LBC were slightly different from those of a conventional aspiration cytology smear.ConclusionLBC is a promising method for improving the standardization of preparations in breast cytology, although care should be taken to account for its characteristic cytologic features. The quantitative analysis of HER-2 mRNA correlated with the results of immunohistochemistry.