Regulation of diet-induced adipose tissue and systemic inflammation by salicylates and pioglitazone.
Regulation of diet-induced adipose tissue and systemic inflammation by salicylates and pioglitazone.
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DOI：
10.1371/journal.pone.0082847
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Lee J
中科院分区：
文献类型：
--
作者：
Kim MS;Yamamoto Y;Kim K;Kamei N;Shimada T;Liu L;Moore K;Woo JR;Shoelson SE;Lee J
人们越来越认识到慢性炎症参与肥胖诱导的胰岛素抵抗和2型糖尿病（T2 D）。水杨酸盐和噻唑烷二酮（TZDs）都具有抗炎和抗高血糖的特性。本研究比较了这些药物对脂肪组织（AT）和AT巨噬细胞（ATM）中肥胖诱导的炎症的影响，以及动物模型的代谢和免疫表型。两种药物均改善高脂饮食（HFD）诱导的胰岛素抵抗。然而，水杨酸盐并不影响AT和ATM炎症，而吡格列酮改善这些参数。有趣的是，HFD和药物治疗都调节了全身炎症，如通过循环免疫细胞数量和激活状态的变化所评估的。HFD增加了循环白色血细胞、中性粒细胞和促炎单核细胞亚群（Ly6Chi）的数量，而水杨酸盐和吡格列酮使这些细胞数量正常化。药物治疗还降低了循环淋巴细胞数量。这些数据表明，肥胖通过调节循环免疫细胞表型诱导全身炎症，并且抗糖尿病干预通过使循环免疫表型正常化来抑制全身炎症。
It is increasingly accepted that chronic inflammation participates in obesity-induced insulin resistance and type 2 diabetes (T2D). Salicylates and thiazolidinediones (TZDs) both have anti-inflammatory and anti-hyperglycemic properties. The present study compared the effects of these drugs on obesity-induced inflammation in adipose tissue (AT) and AT macrophages (ATMs), as well as the metabolic and immunological phenotypes of the animal models. Both drugs improved high fat diet (HFD)-induced insulin resistance. However, salicylates did not affect AT and ATM inflammation, whereas Pioglitazone improved these parameters. Interestingly, HFD and the drug treatments all modulated systemic inflammation as assessed by changes in circulating immune cell numbers and activation states. HFD increased the numbers of circulating white blood cells, neutrophils, and a pro-inflammatory monocyte subpopulation (Ly6Chi), whereas salicylates and Pioglitazone normalized these cell numbers. The drug treatments also decreased circulating lymphocyte numbers. These data suggest that obesity induces systemic inflammation by regulating circulating immune cell phenotypes and that anti-diabetic interventions suppress systemic inflammation by normalizing circulating immune phenotypes.
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影响因子：
82.9
作者：
Arkan, MC;Hevener, AL;Karin, M
通讯作者：
Karin, M
影响因子：
7.7
作者：
Lumeng, Carey N.;DeYoung, Stephanie M.;Saltiel, Alan R.
通讯作者：
Saltiel, Alan R.
影响因子：
39.2
作者：
Goldfine AB;Fonseca V;Jablonski KA;Chen YD;Tipton L;Staten MA;Shoelson SE;Targeting Inflammation Using Salsalate in Type 2 Diabetes Study Team
通讯作者：
Targeting Inflammation Using Salsalate in Type 2 Diabetes Study Team
影响因子：
7.7
作者：
Vozarova, B;Weyer, C;Tataranni, PA
通讯作者：
Tataranni, PA
DOI：
10.1152/ajprenal.00289.2005
发表时间：
2006-03-01
影响因子：
4.2
作者：
Agarwal, R
通讯作者：
Agarwal, R