Selegiline and blood pressure in patients with Parkinson's disease
Selegiline and blood pressure in patients with Parkinson's disease
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DOI：
10.1111/j.1600-0404.2006.00742.x
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发表时间：
2007-02-01
影响因子：
3.5
通讯作者：
Myllyla, V. V.
中科院分区：
文献类型：
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作者：
Pursiainen, V.;Korpelainen, T. J.;Myllyla, V. V.
目标 - 帕金森病 (PD) 经常影响锥体外系和自主神经系统 (ANS)，后者有时也会受到帕金森病药物的干扰。具体而言，已知司来吉兰会扰乱心血管 ANS 功能，并可能导致或加剧体位性低血压。方法 - 为了研究司来吉兰停药对晚期 PD 血压 (BP) 调节的影响，对 14 名 PD 患者进行了体位测试，在早晨左旋多巴剂量之前药效逐渐消失，此后每隔 1 小时重复一次，持续长达 4 小时。每小时还进行统一帕金森病评定量表运动评分评估。经过 4 周的司来吉兰清除期后，重复了这些测试。结果 - 司来吉兰停药可显着降低仰卧位舞台上以及直立测试期间的收缩压。司来吉兰停药后，立位试验中血压的初始下降明显较小。心率不受影响。
Objectives - Parkinson's disease (PD) frequently affects both the extrapyramidal system and the autonomic nervous system (ANS), the latter also being sometimes disturbed by PD medications. Specifically selegiline is known to disturb cardiovascular ANS functions and may cause or enhance orthostatic hypotension. Methods - In order to study the effect of the withdrawal of selegiline on the regulation of blood pressure (BP) in advanced PD, an orthostatic test was performed in 14 PD patients with wearing-off before the morning levodopa dose and thereafter repetitively at 1-h intervals for up to 4 h. A Unified Parkinson's Disease Rating Scale motor score evaluation was also carried out hourly. The tests were repeated after a 4-week selegiline washout period. Results - Selegiline withdrawal decreased systolic BP significantly during the on-stage in a supine position as well as during the orthostatic test. The initial drop of BP in the orthostatic test was significantly smaller after selegiline withdrawal. The heart rate remained unaffected.