Ascaris lumbricoides infection is associated with increased risk of childhood asthma and atopy in rural China
Ascaris lumbricoides infection is associated with increased risk of childhood asthma and atopy in rural China
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DOI：
10.1164/rccm.2107020
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发表时间：
2002-06-01
影响因子：
24.7
通讯作者：
Xu, XP
中科院分区：
文献类型：
--
作者：
Palmer, LJ;Celed贸n, JC;Xu, XP
国际上对蠕虫感染和过敏性疾病之间可能存在的关系越来越感兴趣，尽管这种关系的性质仍然不确定和有争议。目前和过去感染蛔虫的相互关系。对来自中国安庆市的2164名年龄在8至18岁之间的儿童进行了横断面抽样调查。这些儿童的样本来自一个更大的基于家庭的哮喘遗传学研究。有蛔虫病史或粪便检查呈阳性的占24.5%。为了分析目的，使用先前验证的严格标准定义哮喘，包括气道对甲胆碱的反应性。独立于评估的其他因素，类蚓蛔虫感染与哮喘风险增加（p < 0.001）、空气过敏原皮肤试验阳性数量增加（p < 0.001）和甲胆碱剂量反应斜率增加（p = 0.003）相关。在蛔虫感染的儿童中，常见气体过敏原致敏与哮喘风险增加的相关性得到增强，并且这种感染与哮喘风险增加相关，而与空气过敏原致敏无关。这些数据表明，蛔虫病与易感儿童哮喘之间存在复杂的关系，可能与吸入空气过敏原的免疫反应有关。
There is growing international interest in the possible relationships between helminthic infection and allergic disease, although the nature of the relationships remains uncertain and controversial. The interrelationships of current and past infection with Ascaris lumbricoide.s and asthma and atopy were investigated in a cross-sectional sample of 2,164 children between the ages of 8 and 18 years from Anqing Province, China. The children were sampled from a larger family-based study of the genetics of asthma. The prevalence of either a history of or a positive stool examination for Ascaris was 24.5%. Asthma was defined for analytic purposes using previously validated, stringent criteria including airways responsiveness to methacholine. Independently of the other factors assessed, infection with A. lumbricoides was associated with increased risk of asthma (p < 0.001), an increased number of skin tests positive to aeroallergens (p < 0.001), and an increased dose-response slope to methacholine (p = 0.003). The association of sensitization to common aeroallergens with increased asthma risk was enhanced in those children infected with Ascaris, and such infection was associated with an increased risk of asthma independent of sensitization to aeroallergens in this selected population. These data suggest a complex relationship between ascariasis and susceptibility to childhood asthma among predisposed children that may involve an interaction with the immune response to inhaled aeroallergens.