Cardiovascular risk factors, cardiovascular disease, and COVID-19: an umbrella review of systematic reviews.
Cardiovascular risk factors, cardiovascular disease, and COVID-19: an umbrella review of systematic reviews.
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DOI：
10.1093/ehjqcco/qcab029
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发表时间：
2021-07-21
期刊：
影响因子：
--
通讯作者：
Lip GYH
中科院分区：
文献类型：
--
作者：
Harrison SL;Buckley BJR;Rivera-Caravaca JM;Zhang J;Lip GYH
整合证据以确定 (i) 心血管危险因素与 2019 年冠状病毒 (COVID-19) 健康结果之间的关联； (ii) COVID-19 对心血管健康的影响。对系统评价进行了总体审查。 2020 年 1 月 1 日至 2020 年 11 月 5 日期间检索了 14 个医学数据库和预印本服务器。审查重点是使用 AMSTAR 2 工具评为中等或高质量的评论。确定了 84 项审查； 31 条评价为中等质量，1 条评价为高质量。以下风险因素与较高的死亡率和严重的 COVID-19 相关：肾脏疾病 [死亡率的比值比 (OR)（95% 置信区间）3.07 (2.43–3.88)]、糖尿病 [OR 2.09 (1.80–2.42)]、高血压 [OR 2.50 (2.02–3.11)]、吸烟史 [风险比 (RR) 1.26 (1.20–1.32)]、脑血管疾病[RR 2.75 (1.54–4.89)]和心血管疾病[OR 2.65 (1.86–3.78)]。肝病与较高的死亡率相关[OR 2.81 (1.31–6.01)]，但与严重的 COVID-19 无关。当前吸烟与严重 COVID-19 的较高风险相关 [RR 1.80 (1.14–2.85)]，但与死亡率无关。肥胖与较高的死亡率相关[OR 2.18 (1.10–4.34)]，但缺乏严重 COVID-19 的证据。在住院的 COVID-19 患者中，发现了以下心血管并发症：急性心力衰竭 (2%)、心肌梗塞 (4%)、深静脉血栓 (7%)、心肌损伤 (10%)、心绞痛 (10%)、心律失常 (18%)、肺栓塞 (19%) 和静脉血栓栓塞 (25%)。许多被确定与 COVID-19 不良后果相关的风险因素都是可以改变的。针对心血管危险因素的一级和二级预防策略可能会改善 COVID-19 感染者的预后。
To consolidate evidence to determine (i) the association between cardiovascular risk factors and health outcomes with coronavirus 2019 (COVID-19); and (ii) the impact of COVID-19 on cardiovascular health. An umbrella review of systematic reviews was conducted. Fourteen medical databases and pre-print servers were searched from 1 January 2020 to 5 November 2020. The review focused on reviews rated as moderate or high-quality using the AMSTAR 2 tool. Eighty-four reviews were identified; 31 reviews were assessed as moderate quality and one was high-quality. The following risk factors were associated with higher mortality and severe COVID-19: renal disease [odds ratio (OR) (95% confidence interval) for mortality 3.07 (2.43–3.88)], diabetes mellitus [OR 2.09 (1.80–2.42)], hypertension [OR 2.50 (2.02–3.11)], smoking history [risk ratio (RR) 1.26 (1.20–1.32)], cerebrovascular disease [RR 2.75 (1.54–4.89)], and cardiovascular disease [OR 2.65 (1.86–3.78)]. Liver disease was associated with higher odds of mortality [OR 2.81 (1.31–6.01)], but not severe COVID-19. Current smoking was associated with a higher risk of severe COVID-19 [RR 1.80 (1.14–2.85)], but not mortality. Obesity associated with higher odds of mortality [OR 2.18 (1.10–4.34)], but there was an absence of evidence for severe COVID-19. In patients hospitalized with COVID-19, the following incident cardiovascular complications were identified: acute heart failure (2%), myocardial infarction (4%), deep vein thrombosis (7%), myocardial injury (10%), angina (10%), arrhythmias (18%), pulmonary embolism (19%), and venous thromboembolism (25%). Many of the risk factors identified as associated with adverse outcomes with COVID-19 are potentially modifiable. Primary and secondary prevention strategies that target cardiovascular risk factors may improve outcomes for people following COVID-19.
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影响因子：
8.3
作者：
Banerjee A;Chen S;Pasea L;Lai AG;Katsoulis M;Denaxas S;Nafilyan V;Williams B;Wong WK;Bakhai A;Khunti K;Pillay D;Noursadeghi M;Wu H;Pareek N;Bromage D;McDonagh TA;Byrne J;Teo JTH;Shah AM;Humberstone B;Tang LV;Shah ASV;Rubboli A;Guo Y;Hu Y;Sudlow CLM;Lip GYH;Hemingway H
通讯作者：
Hemingway H
影响因子：
2.7
作者：
Luo L;Fu M;Li Y;Hu S;Luo J;Chen Z;Yu J;Li W;Dong R;Yang Y;Tu L;Xu X
通讯作者：
Xu X
影响因子：
105.7
作者：
Docherty, Annemarie B.;Harrison, Ewen M.;Semple, Malcolm G.
通讯作者：
Semple, Malcolm G.
影响因子：
39.3
作者：
Madjid, Mohammad;Miller, Charles C.;Casscells, Samuel Ward, III
通讯作者：
Casscells, Samuel Ward, III
影响因子：
34.3
作者：
Clark, Andrew;Jit, Mark;Eggo, Rosalind M.
通讯作者：
Eggo, Rosalind M.