Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition.
Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition.
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胸腺调节性T（Treg）细胞的产生需要白细胞介素2（IL-2）和激动剂TCR配体，并且通过竞争有限的发育小生境来控制，但是对IL-2的胸腺来源和限制进入小生境的因素知之甚少。在这里，我们表明，IL-2产生的抗原的树突状细胞在Treg细胞的发展中起着关键作用，现有的Treg细胞限制新的Treg细胞的发展，通过竞争IL-2。.我们的数据表明，可以提供IL-2和TCR配体的抗原呈递细胞包括胸腺小生境，并且现有Treg细胞对有限供应的IL-2的竞争为新Treg细胞的产生提供了负反馈。
Thymic regulatory T (Treg) cell production requires interleukin 2 (IL-2) and agonist TCR ligands, and is controlled by competition for a limited developmental niche, but the thymic sources of IL-2 and the factors that limit access to the niche are poorly understood. Here we show that IL-2 produced by antigen-bearing dendritic cells plays a key role in Treg cell development, and that existing Treg cells limit new Treg cell development by competing for IL-2. . Our data suggest that antigen-presenting cells that can provide both IL-2 and a TCR ligand comprise the thymic niche, and that competition by existing Treg cells for a limited supply of IL-2 provides negative feedback for new Treg cell production.
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