Anti-glial nuclear antibody: Marker of lung cancer-related paraneoplastic neurological syndromes
Anti-glial nuclear antibody: Marker of lung cancer-related paraneoplastic neurological syndromes
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DOI：
10.1016/j.jneuroim.2005.03.020
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发表时间：
2005-08-01
影响因子：
3.3
通讯作者：
Dalmau, J
中科院分区：
文献类型：
--
作者：
Graus, F;Vincent, A;Dalmau, J
我们描述了一种新的抗体，称为抗胶质核抗体（AGNA），用于副肿瘤神经综合征（PNS）和小细胞肺癌（SCLC）患者。通过免疫组化对24份档案大鼠小脑血清进行AGNA鉴定。AGNA阳性血清浦肯野细胞层伯格曼胶质细胞呈特征性核染色。免疫印迹和用AGNA血清检测小脑表达文库均未发现抗原。24例AGNA患者中有20例患有PNS，除2例外均患有肺癌。AGNA在13/113（11.5%）的SCLC患者中被发现，而在其他类型的癌症中为0/122 (p
We describe a new antibody, called anti-glial nuclear antibody (AGNA), in patients with paraneoplastic neurological syndromes (PNS) and small-cell lung carcinoma (SCLC). AGNA was initially identified in 24 sera of our archives by immunohistochemistry on rat cerebellum. AGNA positive sera showed a characteristic nuclear staining of the Bergmann glia in the Purkinje cell layer. Immunoblots and probing a cerebellar expression library with AGNA sera did not identify the antigen. Twenty of the 24 patients with AGNA had PNS and all but two had lung cancer. AGNA was identified in 13/113 (11.5%) patients with SCLC compared with 0/122 with other types of cancer (p