TURNOVER RATE OF PLASMA FFA AND RATE OF ESTERIFICATION OF PLASMA FFA TO PLASMA TRIGLYCERIDES IN OBESE HUMANS BEFORE AND AFTER WEIGHT REDUCTION
TURNOVER RATE OF PLASMA FFA AND RATE OF ESTERIFICATION OF PLASMA FFA TO PLASMA TRIGLYCERIDES IN OBESE HUMANS BEFORE AND AFTER WEIGHT REDUCTION
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DOI：
10.1016/0026-0495(69)90129-2
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发表时间：
1969-01-01
期刊：
影响因子：
9.8
通讯作者：
TJABBES, T
中科院分区：
文献类型：
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作者：
BIRKENHAGER, JC;TJABBES, T
采用恒定微量输注技术给予 palmitate-1-14C，FFA 通量率为 286–654μEq./min。在 5 名对照受试者中发现（平均 533），而通量率为 663–959 μEq./min。 （平均 837）在 5 名未经治疗的肥胖患者中。当以每千克去脂体重 (LBM)（通过 40K 全身计数获得）表示时，肥胖人群的 FFA 通量率（16.98–24.78 μEq./min.Kg.LBM，平均 20.49）比对照组（9.17–14.31，平均 11.55）高得多。间歇性饥饿治疗并没有直接影响这种高脂肪分解率。体重达到正常 1.5 个月后，一名仅接受热量限制治疗的患者表现出先前较高的 FFA 周转率正常化。对 2 名嗜铬细胞瘤患者（脂肪分解率高，术后纠正）和 1 名神经性厌食症患者（体内脂肪量减少）进行了上述参数的比较研究。人们认为，在人类“外源性”肥胖的发病机制中，脂解作用的受损可能并不是主要涉及的。当以μmole/min./L.plasma 表示时，肥胖患者的血浆甘油三酯流入率高于对照组。这种高酯化率在饥饿处理后不久也没有显示出降低。
With a constant microinfusion technique for administration of palmitate-1-14C, a FFA flux rate of 286–654μEq./min. (average 533) was found in 5 control subjects as against a flux rate of 663–959 μEq./min. (average 837) in 5 untreated obese patients. When expressed per kilogram lean body mass (LBM) (obtained by whole body counting of40K) the FFA flux rate was considerably higher in the obese people (16.98–24.78 μEq./min. Kg. LBM, average 20.49) than in the controls (9.17–14.31, average 11.55). Treatment by intermittent starvation did not directly affect this high rate of lipolysis. 1.5 months after having reached a normal body weight, one patient, treated by calorie-restriction only, exhibited normalization of the previously high FFA turnover rate. A comparative study of the mentioned parameters was made in 2 patients with a pheochromocytoma (with a high lipolysis rate, corrected after operation) and 1 patient suffering from anorexia nervosa (with a depleted body fat mass). It is considered probable that in the pathogenesis of human “exogenous” obesity, impairment of lipolysis is not primarily involved. The plasma triglyceride influx rate in the obese patients was high as compared to that in the controls, when expressed as μmole/min./L.plasma. This high rate of esterification, too, showed no diminishment shortly after starvation treatment.