The contribution of HLA class I antigens in immune status following two doses of rubella vaccination
The contribution of HLA class I antigens in immune status following two doses of rubella vaccination
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DOI：
10.1016/j.humimm.2004.07.001
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发表时间：
2004-12-01
期刊：
影响因子：
2.7
通讯作者：
Poland, GA
中科院分区：
文献类型：
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作者：
Ovsyannikova, IG;Jacobson, RM;Poland, GA
由人类白细胞抗原（HLA）基因调节的体液和细胞免疫反应的变异性是风疹疫苗保护作用的一个重要因素。我们对 346 名之前接种过两剂麻疹、腮腺炎、风疹 II 疫苗的健康学童和年轻人进行了 HLA I 类分型。评估了风疹病毒特异性体液（血清抗体）免疫和细胞介导的免疫（淋巴细胞增殖）。抗体水平和刺激指数(SI)的中值分别为38.63 IU/ml和2.29 IU/ml。提供 HLA 与风疹血清阳性相关性的提示性而非决定性证据的等位基因为 HLA-B*2705（中位数，24.68 IU/ml；p = 0.160）、B*4501（中位数，61.22 IU/ml；p = 0.098）、Cw*0303（中位数，30.34 IU/ml；p = 0.102）和 Cw*0704（中位数，26.58 IU/ml；p = 0.144）。这些等位基因接近但未达到统计显着性。在分析的所有等位基因中，HLA-B*3503（SI 中位数，3.00；p = 0.031）和 HLA-Cw*1502（SI 中位数，3.19；p = 0.035）与风疹病毒抗原的淋巴细胞增殖反应呈正相关，而 HLA-B*3901（SI，1.34；p = 0.066）等位基因呈负相关。这表明 I 类 HLA 等位基因可能与风疹疫苗的体液和细胞免疫反应关系有限。这些数据可能有助于我们了解遗传远交异质群体中的免疫反应变异。 (C) 美国组织相容性和免疫遗传学学会，2004 年。由 Elsevier Inc. 出版。
The variability of humoral and cellular immune responses modulated by human leukocyte antigen (HLA) genes is a significant factor in the protective effect of rubella vaccines. We performed HLA class I typing in a group of 346 healthy schoolchildren and young adults who previously received two doses of measles-mumps-rubella-II vaccine. Rubella virus-specific humoral (serum antibody) immunity and cell-mediated immunity (lymphocyte proliferation) were assessed. Median values for antibody levels and stimulation indices (SI) were 38.63 IU/ml and 2.29 IU/ml, respectively. The alleles that provided suggestive, but not conclusive, evidence of HLA association with rubella seropositivity were HLA-B*2705 (median, 24.68 IU/ml; p = 0.160), B*4501 (median, 61.22 IU/ml; p = 0.098), Cw*0303 (median, 30.34 IU/ml; p = 0.102) and Cw*0704 (median, 26.58 IU/ml; p = 0.144). These alleles approach, but do not achieve, statistical significance. Of all the alleles analyzed, HLA-B*3503 (median SI, 3.00; p = 0.031) and HLA-Cw*1502 (median SI, 3.19; p = 0.035) were positively associated with lymphoproliferative responses to rubella virus antigens, whereas the HLA-B*3901 (SI, 1.34; p = 0.066) allele was negatively associated. This suggests that class I HLA alleles may have limited associations with humoral and cellular immune responses to rubella vaccine. These data may facilitate our understanding of immune response variation in a genetically outbred heterogeneous population. (C) American Society for Histocompatibility and Immunogenetics, 2004. Published by Elsevier Inc.