VARICELLA-ZOSTER-ASSOCIATED ENCEPHALITIS - DETECTION OF SPECIFIC ANTIBODY IN CEREBROSPINAL-FLUID
VARICELLA-ZOSTER-ASSOCIATED ENCEPHALITIS - DETECTION OF SPECIFIC ANTIBODY IN CEREBROSPINAL-FLUID
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DOI：
10.1128/jcm.12.6.764-767.1980
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发表时间：
1980-01-01
影响因子：
9.4
通讯作者：
TABER, L
中科院分区：
文献类型：
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作者：
GERSHON, A;STEINBERG, S;TABER, L
采用间接免疫荧光法检测水痘-带状疱疹病毒（VZ）抗体，以鉴别VZ病毒脑炎患者。在15/16例（94%）有VZ感染和CNS受累临床证据的患者中，CSF中VZ抗体滴度为1：2或更高。在7例无CNS受累临床体征的VZ感染患者的脑脊液中未检测到VZ抗体，在25例恶性或脱髓鞘疾病或脑炎患者的CSF中也未检测到任何VZ抗体，这是由于其他病毒或毒性因子所致。所有患者血清VZ抗体均可检测到。在这项研究中，通过间接免疫荧光法测定的CSF中可检测到的VZ抗体的存在似乎与该病毒导致CNS受累的临床证据相关。
Varicella-zoster (VZ) antibody measured by indirect immunofluorescence was used to identify patients with encephalitis due to VZ virus. In 15 of 16 (94%) patients with VZ infection and clinical evidence of CNS involvement, VZ antibody was present at a titer of 1:2 or greater in CSF. No VZ antibody was detected in the cerebrospinal fluid of 7 patients with VZ infections without clinical signs of CNS involvement, nor was any detected in the CSF of 25 patients with malignant or demyelinating disease or encephalitis, due to other viral or toxic agents. All of these patients had detectable serum VZ antibody. In this study the presence of detectable VZ antibody in CSF measured by indirect immunofluorescence seemed to correlate with clinical evidence of CNS involvment due to this virus.