MicroRNAs involved in tumor suppressor and oncogene pathways: implications for hepatobiliary neoplasia.
MicroRNAs involved in tumor suppressor and oncogene pathways: implications for hepatobiliary neoplasia.
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DOI：
10.1002/hep.23010
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发表时间：
2009-08
期刊：
影响因子：
13.5
通讯作者：
Mott, Justin L.
中科院分区：
文献类型：
--
作者：
Mott, Justin L.
MicroRNA是一类小的调节RNA，其功能是调节蛋白质表达。这种控制允许细胞表型的微调，包括增殖，细胞信号传导和凋亡的调节;毫不奇怪，microRNA有助于肝癌生物学。最近在人类肝癌和肿瘤衍生细胞系中的研究已经证明了特定microRNA在肝胆癌细胞中的表达减少或增加。基于预测和验证的蛋白质靶点以及表达改变的功能后果，在肝肿瘤细胞中表达降低的microRNA通常可能有助于限制肿瘤转化。相反，在肝肿瘤细胞中上调的选定的microRNA可以促进恶性特征，从而促进致癌作用。此外，microRNA本身也受到调控表达，包括通过肿瘤抑制和癌基因途径进行调控。本文就肿瘤相关microRNA的表达和功能，包括其在肝胆肿瘤相关的抑癌基因和癌基因信号网络中的作用进行综述。
MicroRNAs are a class of small regulatory RNAs that function to modulate protein expression. This control allows for fine-tuning of the cellular phenotype, including regulation of proliferation, cell signaling, and apoptosis; not surprisingly, microRNAs contribute to liver cancer biology. Recent investigations in human liver cancers and tumor-derived cell lines have demonstrated decreased or increased expression of particular microRNAs in hepatobiliary cancer cells. Based on predicted and validated protein targets as well as functional consequences of altered expression, microRNAs with decreased expression in liver tumor cells may normally aid in limiting neoplastic transformation. Conversely, selected microRNAs that are upregulated in liver tumor cells can promote malignant features, contributing to carcinogenesis. In addition, microRNAs themselves are subject to regulated expression, including regulation by tumor suppressor and oncogene pathways. This review will focus on the expression and function of cancer-related microRNAs, including their intimate involvement in tumor suppressor and oncogene signaling networks relevant to hepatobiliary neoplasia.
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