Cytogenetic analysis of human preimplantation embryos following developmental arrest in vitro
Cytogenetic analysis of human preimplantation embryos following developmental arrest in vitro
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DOI：
10.1071/rd98040
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发表时间：
1998-01-01
影响因子：
1.9
通讯作者：
Bolton, VN
中科院分区：
文献类型：
--
作者：
Almeida, PA;Bolton, VN
本文研究了人类植入前胚胎染色体异常与体外发育停滞的关系。对171个停滞在原核期至8细胞期的胚胎进行细胞遗传学分析，发现染色体异常的发生率为63.4%。在原核期（n = 48）的胚胎中，47.9%的胚胎染色体异常，而在2-和4-细胞期（n = 50）之间的胚胎染色体异常率为59.5%，在5-和8-细胞期（n = 73）之间的胚胎染色体异常率为82.8%。形态不佳胚胎（卵裂球形状不规则，细胞外碎片较多）的畸形率（86.8%; n = 33）显著高于形态良好胚胎（60%; n = 51; P
The relationship between chromosomal abnormalities in the human preimplantation embryo and developmental arrest in vitro was investigated. Cytogenetic analysis of 171 embryos that had arrested between the pronucleate and the 8-cell stages demonstrated that the overall incidence of chromosomal abnormality among these embryos was 63.4%. Of the embryos that arrested at the pronucleate stage (n = 48), 47.9% were chromosomally abnormal, compared with 59.5% of those that arrested between the 2- and 4-cell stages (n = 50), and 82.8% of those arrested between the 5- and 8-cell stage (n = 73). The rate of abnormality in embryos with poor morphology (irregular shaped blastomeres and considerable extracellular fragmentation) was significantly higher (86.8%; n = 33) than those with good morphology (60%; n = 51; P