Lysophosphatidic acid and signaling in sensory neurons
Lysophosphatidic acid and signaling in sensory neurons
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DOI：
10.1016/j.bbalip.2014.09.004
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发表时间：
2015-01-01
影响因子：
4.8
通讯作者：
Beuers, Ulrich H.
中科院分区：
文献类型：
--
作者：
Elferink, Ronald P. J. Oude;Bolier, Ruth;Beuers, Ulrich H.
溶血磷脂酸是一种有效的信号脂质分子，最初被认为是一种生长因子。然而，后来的研究揭示了更多的功能，如调节细胞形状、细胞迁移、防止细胞凋亡、血小板聚集、伤口愈合、破骨细胞分化、血管加压活性、胚胎着床、血管生成、肺纤维化、毛发生长等。该分子主要通过激活一组至少6个g蛋白偶联受体（LPA1-6）起作用，但细胞内LPA也被证明通过激活核受体PPAR γ发出信号。在这篇简短的综述中，我们讨论了最近的观察结果，表明在病理条件下LPA也调节感觉神经元的信号。因此，LPA已被证明在神经性疼痛的开始发挥作用，最近，在循环中观察到LPA水平升高与胆汁淤积性瘙痒之间的关系。这种现象发生的机制还有待阐明。这篇文章是题为在脂肪组学中连接转录与生理的特刊的一部分。(C) 2014 Elsevier B.V.版权所有
Lysophosphatidic acid is a potent signaling lipid molecule that has initially been characterized as a growth factor. However, later studies have revealed many more functions such as modulation of cell shape, cell migration, prevention of apoptosis, platelet aggregation, wound healing, osteoclast differentiation, vasopressor activity, embryo implantation, angiogenesis, lung fibrosis, hair growth and more. The molecule mainly acts through the activation of a set of at least 6 G-protein-coupled receptors (LPA1-6), but intracellular LPA was also shown to signal through the activation of the nuclear receptor PPAR gamma. In this short review we discuss the recent observations which suggest that in pathological conditions LPA also modulates signaling in sensory neurons. Thus, LPA has been shown to play a role in the initiation of neuropathic pain and, more recently, a relation was observed between increased LPA levels in the circulation and cholestatic itch. The mechanism by which this occurs remains to be elucidated. This article is part of a Special Issue entitled Linking transcription to physiology in lipodomics. (C) 2014 Elsevier B.V. All rights reserved.