High immunosuppressive burden in advanced hepatocellular carcinoma patients: Can effector functions be restored?
High immunosuppressive burden in advanced hepatocellular carcinoma patients: Can effector functions be restored?
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DOI：
10.4161/onci.24679
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发表时间：
2013-07-01
期刊：
影响因子：
7.2
通讯作者：
Thanavala Y
中科院分区：
文献类型：
--
作者：
Lugade AA;Kalathil S;Miller A;Iyer R;Thanavala Y
免疫抑制细胞和耗竭效应T细胞的积累突出了晚期肝细胞癌（HCC）患者的重要免疫功能障碍。这些细胞明显阻碍免疫治疗的效果，并促进HCC的进展。我们最近已经证明，免疫抑制细胞的多管齐下的消耗可能恢复HCC中的效应t细胞功能。
The accumulation of immunosuppressive cells and exhausted effector T cells highlight an important immune dysfunction in advanced stage hepatocellular carcinoma (HCC) patients. These cells significantly hamper the efficacy immunotherapies and facilitate HCC progression. We have recently demonstrated that the multipronged depletion of immunosuppressive cells potentially restores effector T-cell function in HCC.