Changes in brain architecture are consistent with altered fear processing in domestic rabbits
Changes in brain architecture are consistent with altered fear processing in domestic rabbits
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DOI：
10.1073/pnas.1801024115
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发表时间：
2018-07-10
影响因子：
11.1
通讯作者：
Andersson, Leif
中科院分区：
文献类型：
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作者：
Brusini, Irene;Carneiro, Miguel;Andersson, Leif
家养动物最典型的特征是它们在行为上的变化，这种变化与驯化的选择有关。在这里，我们显示，使用高分辨率的脑磁共振成像在野生和家养兔子，驯化减少杏仁核体积和扩大内侧前额叶皮质体积，支持驱动恐惧的区域已经失去了体积，而区域调制负面影响在驯化过程中获得了体积。与局部灰质改变相反，放射冠、胼胝体和皮质下白色物质的白色各向异性降低。这表明投射和联合纤维中的白色结构完整性受损，影响传入和传出神经流，与神经处理减少一致。我们认为，与它们的野生祖先相比，由于大脑结构的这些变化，家兔不那么害怕，并且具有减弱的飞行反应。
The most characteristic feature of domestic animals is their change in behavior associated with selection for tameness. Here we show, using high-resolution brain magnetic resonance imaging in wild and domestic rabbits, that domestication reduced amygdala volume and enlarged medial prefrontal cortex volume, supporting that areas driving fear have lost volume while areas modulating negative affect have gained volume during domestication. In contrast to the localized gray matter alterations, white matter anisotropy was reduced in the corona radiata, corpus callosum, and the subcortical white matter. This suggests a compromised white matter structural integrity in projection and association fibers affecting both afferent and efferent neural flow, consistent with reduced neural processing. We propose that compared with their wild ancestors, domestic rabbits are less fearful and have an attenuated flight response because of these changes in brain architecture.