Consumption of black tea and cancer risk: A prospective cohort study
Consumption of black tea and cancer risk: A prospective cohort study
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DOI：
10.1093/jnci/88.2.93
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发表时间：
1996-01-17
影响因子：
10.3
通讯作者：
vandenBrandt, PA
中科院分区：
文献类型：
--
作者：
Goldbohm, RA;Hertog, MGL;vandenBrandt, PA
背景:茶是世界上最常消费的饮料之一，抗氧化多酚化合物（如儿茶素和黄酮醇）在绿茶和红茶中都大量存在，并且在细胞和动物模型研究中被观察到具有抗癌特性，然而，在红茶中，大多数儿茶素被氧化成可能降低抗癌特性的形式，尽管实验研究表明茶可以预防癌症，流行病学证据尚无定论，目的：荷兰饮食与癌症队列研究对58,279名男性和62,573名年龄在55-69岁之间的女性进行了红茶消费与胃癌，结肠直肠癌，肺癌和乳腺癌风险之间的关系进行了调查。方法：队列中的受试者在1986年完成了一份关于饮食习惯和其他癌症风险因素的自我管理问卷。通过与荷兰所有9个地区癌症登记处和国家病理数据库的计算机记录链接进行癌症随访，在4.3年的随访期间，分别诊断出200例，650例，764例和650例胃癌，结肠直肠癌，肺癌和乳腺癌。研究人员使用调查问卷和随机亚队列（n = 3500）的数据来计算红茶消费者与非红茶消费者的癌症发病率比（rr）。结果：13%的受试者不喝茶，而37%、34%和16%的受试者分别每天喝一到两杯、三到四杯、五杯或更多的茶。没有观察到喝茶和结直肠癌风险之间的联系：每种消费类别中喝茶的人的风险与不喝茶的人相似。每天饮茶5杯以上的人患乳腺癌的风险比为1.3(95%可信区间= 0.9-2.0)；未观察到剂量-反应关联。在年龄和性别调整分析中，喝茶与胃（趋势的双侧P值= 0.147）和肺（趋势的双侧P值）呈负相关
Background: Tea is ope of the most frequently consumed beverages in the world, Antioxidant polyphenol compounds (such as catechins and flavonols) are abundantly present in both green and black teas and have been observed to have anticarcinogenic properties in cell and animal model studies, In black tea, however, most of the catechins have been oxidized to forms that may have reduced anticarcinogenic properties, Despite indications from experimental studies that tea may protect against cancer, epidemiologic evidence has been inconclusive, Purpose: The association between black tea consumption and the subsequent risk of stomach, colorectal, lung, and breast cancers was investigated in The Netherlands Cohort Study on Diet and Cancer among 58 279 men and 62 573 women aged 55-69 years, Methods: Subjects in the cohort completed a self-administered questionnaire on dietary habits and other risk factors for cancer at base Line in 1986. Follow-up for cancer was done by means of computerized record linkage with all nine regional cancer registries in The Netherlands and the national pathology database, During 4.3 years of follow-up, 200, 650, 764, and 650 cases of stomach, colorectal, lung, and breast cancers were diagnosed, respectively. The questionnaire data of case subjects and those of a random subcohort (n = 3500) were used to calculate rate ratios (RRs) of cancer in categories of consumers of black tea compared with nonconsumers. Results: Tea was not used by 13% of the subjects in the cohort, whereas 37%, 34%, and 16% consumed one to two, three to four, and five or more cups of tea per day, respectively, No association was observed between tea consumption and risk of colorectal cancer: The risk among tea drinkers in each consumption category was similar to that among nondrinkers. The RR of breast cancer among consumers of five or more cups of tea per day was 1.3 (95 % confidence interval = 0.9-2.0); no dose-response association was observed. In age- and sex-adjusted analyses, consumption of tea was inversely associated with stomach (two-sided P for trend = .147) and lung (two-sided P for trend