Functional activation in the auditory system of the rat produced by arousing reticular stimulation: a 2-deoxyglucose study
Functional activation in the auditory system of the rat produced by arousing reticular stimulation: a 2-deoxyglucose study
复制标题
网状刺激引起的大鼠听觉系统的功能激活：2-脱氧葡萄糖研究
DOI：
10.1016/0006-8993(84)90702-9
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发表时间：
1984
期刊：
影响因子：
2.9
通讯作者：
H. Scheich
中科院分区：
文献类型：
--
作者：
F. Gonzalez;H. Scheich
本文用2-脱氧葡萄糖（2-DG）放射自显影法研究了行为性电刺激中脑网状结构（RET）时听觉通路的活动。将RET刺激期间2-DG的摄取与调频音（4-5 kHz，60 dB SPL）的效果和无刺激的对照进行比较。主要发现是RET刺激期间诱发的整个听觉通路的代谢活化增加的特定模式。观察到的增加2-DG摄取始终是更大的RET刺激的大鼠相比，声音刺激或对照组大鼠。耳蜗背核（DCN）的2-DG掺入量最大的听觉核团的脑干在RET刺激的大鼠。在下丘中央核的分层模式由3个离散的高2-DG摄取带是可见的RET刺激的大鼠。内侧膝状体（MG）和听觉皮层（AC）也表现出高度显着增加2-DG摄取诱导RET刺激。该方法提供了经典的细胞核和功能定义的领域增加2-DG摄取的包裹形态计划之间的相关性。我们的观察代表了第一次解剖学演示的RET刺激在感觉系统中的激活作用，他们支持的概念，唤起网状机制的感觉控制。
The 2-deoxyglucose (2-DG) autoradiographic method was used to map the activity in the auditory pathway during behaviorally arousing electrical stimulation of the mesencephalic reticular formation (RET). Uptake of 2-DG during RET stimulation was compared to the effect of a frequency-modulated tone (4–5 kHz, 60 dB SPL) and to controls without stimulation. The major finding was a specific pattern of increased metabolic activation throughout the auditory pathway evoked during RET stimulation. The observed increases in 2-DG uptake were always greater in RET-stimulated rats as compared to sound-stimulated or control rats. The dorsal cochlear nucleus (DCN) showed the largest incorporation of 2-DG among the auditory nuclei of the brainstem in RET-stimulated rats. In the central nucleus of the inferior colliculus a layered pattern made of 3 discrete bands of high 2-DG uptake was visible in RET-stimulated rats. The medial geniculate (MG) and the auditory cortex (AC) also showed highly significant increases in 2-DG uptake induced by RET stimulation. The method provided correlations between classical morphological schemes of parcellation on nuclei and functionally defined areas of increased 2-DG uptake. Our observations represent the first anatomical demonstration of the activating effects of RET stimulation in a sensory system, and they support the concepts of arousing reticular mechanisms for sensory control.