Increased serum leukocyte cell-derived chemotaxin 2 (LECT2) levels in obesity and fatty liver
Increased serum leukocyte cell-derived chemotaxin 2 (LECT2) levels in obesity and fatty liver
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DOI：
10.5582/bst.2013.v7.6.276
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发表时间：
2013-01-01
影响因子：
5.5
通讯作者：
Kaburagi, Yasushi
中科院分区：
文献类型：
--
作者：
Okumura, Akinori;Unoki-Kubota, Hiroyuki;Kaburagi, Yasushi
白细胞源趋化因子2（LECT 2）是一种在肝脏中表达的信号分子，并受与肝脏代谢有关的Wnt/β-连环蛋白途径调节。然而，LECT 2在肥胖和脂肪肝中的临床相关性尚不清楚。本研究的目的是确定血清LECT 2水平是否受肥胖和脂肪肝的影响。一项包括231名日本成年受试者的横断面研究使用高灵敏度测定法检测LECT 2。我们评估了LECT 2与肥胖和脂肪肝的人体测量或临床标志物之间的关联。平均血清LECT 2水平为43.5 +/- 13.6 ng/mL。LECT 2与所有肥胖的人体测量指标呈正相关：体重指数、腰围、腰臀比和腰高比（W/Ht）。多元回归分析显示，LECT 2是独立相关的γ-谷氨酰转肽酶（γ-GTP），甘油三酯，男性和年龄，而在女性中，它与稳态模型评估比，血尿素氮，高密度脂蛋白胆固醇，γ-GTP。受试者工作特征曲线分析显示LECT 2与肥胖相关[男性曲线下面积（AUC）0.655，95%置信区间（CI）= 0.551-0.758，p = 0.002; AUC 0.670，95% CI = 0.570-0.770，p < 0.001（雌性）]和脂肪肝（男性AUC 0.646，95% CI = 0.544-0.749，p = 0.004;女性AUC 0.733，95% CI = 0.621-0.844，p < 0.001）。目前的研究表明，血清LECT 2水平增加肥胖和脂肪肝，并建议LECT 2是一种新的肥胖相关蛋白。
Leukocyte cell-derived chemotaxin 2 (LECT2) is a signaling molecule expressed in the liver and regulated by Wnt/beta-catenin pathways implicated in hepatic metabolism. However, the clinical relevance of LECT2 in obesity and fatty liver is unknown. The objective of this study was to determine whether serum LECT2 levels are affected by of obesity and fatty liver. A cross sectional study comprising 231 Japanese adult subjects were tested for LECT2 using a highly sensitive assay. We evaluated the associations between LECT2 and the anthropometric or clinical markers of obesity and fatty liver. The mean serum LECT2 levels were 43.5 +/- 13.6 ng/mL. LECT2 positively correlated with all the anthropometric measures of obesity: body mass index, waist circumference, waist-to-hip ratio, and waist-to-height ratio (W/Ht). Multiple regression analysis revealed that LECT2 is independently related to gamma-glutamyl transpeptidase (gamma-GTP), triglyceride, and age in males, whereas in females it was related to the homeostasis model assessment ratio, blood urea nitrogen, high-density lipoprotein cholesterol, and gamma-GTP. Receiver operating characteristics curve analyses revealed that LECT2 correlated with obesity [area under the curve (AUC) 0.655, 95% confidence interval (CI) = 0.551-0.758, p = 0.002 in males; AUC 0.670, 95% CI = 0.570-0.770, p < 0.001 in females] and fatty liver (AUC 0.646, 95% CI = 0.544-0.749, p = 0.004 in males; AUC 0.733, 95% CI = 0.621-0.844, p < 0.001 in females). The present study indicates that serum LECT2 levels are increased by obesity and fatty liver, and suggests that LECT2 is a novel obesity-related protein.