C-reactive protein levels are influenced by common Il-1 gene variations
C-reactive protein levels are influenced by common Il-1 gene variations
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DOI：
10.1006/cyto.2001.0974
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发表时间：
2002-02-21
期刊：
影响因子：
3.8
通讯作者：
Duff, GW
中科院分区：
文献类型：
--
作者：
Berger, P;McConnell, JP;Duff, GW
全身炎症标志物升高与急性冠状动脉综合征的发生有关，但目前还没有明显健康个体炎症增加的解释。炎症反应的遗传控制对观察到的变异性的影响尚不清楚。我们研究了454名接受冠状动脉造影的个体中已知可调节炎症的白细胞介素（IL）1基因的四种多态性的频率，并分析了它们对血浆C反应蛋白（CRP）和纤维蛋白原水平的影响。女性和吸烟者的CRP水平高于男性（Pi=0.001）和非吸烟者（Pi=0.001）。IL-1B（+3954）多态性基因型为2.2的患者的中位CRP水平是基因型为1.1的患者的两倍（4.33 vs 2.01 mg/l; P=0.001）。IL-1A（+4845）多态性基因型为1.2或2.2的患者中位CRP也较高（2.92 vs 2.05 mg/l，Pi=0.023）。在多变量分析中，在调整吸烟、性别和年龄后，CRP水平仍与IL-1多态性显著相关。纤维蛋白原水平与IL-1基因型有相似的相关性。这些数据表明，已知影响炎症反应的IL-1基因多态性与冠状动脉造影患者的CRP和纤维蛋白原血浆水平高度相关。(C)2002爱思唯尔科技有限公司版权所有。
Elevated markers of systemic inflammation are associated with the development of acute coronary syndromes, but there is no current explanation for increased inflammation in overtly healthy individuals. The influence of genetic control of the inflammatory response on the observed variability is unknown. We studied the frequency of four polymorphisms in interleukin (IL) 1 genes, known to modulate inflammation, in 454 individuals undergoing coronary angiography and analysed their influence on plasma C-reactive protein (CRP) and fibrinogen levels. Females and smokers had higher levels of CRP than males (Pi=0.001) and non-smokers (Pi=0.001). Patients with genotype 2.2 for the IL-1B(+3954) polymorphism had twice the median CRP levels of patients who were genotype 1.1 (4.33 vs 2.01 mg/l; P=0.001). Patients with genotype 1.2 or 2.2 at the IL-1A(+4845) polymorphism also had higher median CRP (2.92 vs 2.05 mg/l, Pi=0.023). In multivariate analyses, CRP levels remained significantly associated with IL-1 polymorphisms after adjustment for smoking, gender and age. Fibrinogen levels had similar associations with the IL-1 genotypes. These data indicate that IL-1 gene polymorphisms known to affect the inflammatory response are highly related to plasma levels of CRP and fibrinogen in patients referred for coronary angiography. (C) 2002 Elsevier Science Ltd. All rights reserved.