Cistrome Cancer: A Web Resource for Integrative Gene Regulation Modeling in Cancer.
Cistrome Cancer: A Web Resource for Integrative Gene Regulation Modeling in Cancer.
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DOI：
10.1158/0008-5472.can-17-0327
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发表时间：
2017-11-01
期刊：
影响因子：
11.2
通讯作者：
Liu XS
中科院分区：
文献类型：
--
作者：
Mei S;Meyer CA;Zheng R;Qin Q;Wu Q;Jiang P;Li B;Shi X;Wang B;Fan J;Shih C;Brown M;Zang C;Liu XS
癌症的发生是由于正常基因表达控制的破坏，因此基因调控的研究对癌症研究至关重要。为了深入了解调节癌症中异常基因表达模式的转录和表观遗传因子，我们开发了Cistrome Cancer网络资源（http：//cistrome.org/CistromeCancer/）。我们对来自癌症基因组图谱（TCGA）的一万多个肿瘤分子谱与来自我们的Cistrome集合的超过2.3万个ChIP-seq和染色质可及性谱进行了系统整合和建模。结果包括功能增强子谱的重建，“超级增强子”靶基因，以及对每种TCGA癌症类型的活性转录因子（TF）及其靶基因的预测。Cistrome癌症揭示了新的见解，从综合分析结合染色质谱与肿瘤分子谱，将是一个有用的资源，癌症基因调控社区。
Cancer results from a breakdown of normal gene expression control, so the study of gene regulation is critical to cancer research. To gain insight into the transcriptional and epigenetic factors regulating abnormal gene expression patterns in cancers, we developed the Cistrome Cancer web resource (http://cistrome.org/CistromeCancer/). We conducted the systematic integration and modeling of over ten thousand tumor molecular profiles from The Cancer Genome Atlas (TCGA) with over twenty-three thousand ChIP-seq and chromatin accessibility profiles from our Cistrome collection. The results include reconstruction of functional enhancer profiles, “super-enhancer” target genes, as well as predictions of active transcription factors (TF) and their target genes for each TCGA cancer type. Cistrome Cancer reveals novel insights from integrative analyses combining chromatin profiles with tumor molecular profiles, and will be a useful resource to the cancer gene regulation community.